Before taking pyrimethamine, tell your doctor if you have
- had an allergic reaction to previous treatment with pyrimethamine,
- megaloblastic anemia due to folate deficiency,
- seizures or epilepsy,
- kidney disease, or
- liver disease.
You may not be able to take pyrimethamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
Pyrimethamine is in the FDA pregnancy category C. This means that it is not known whether pyrimethamine will be harmful to an unborn baby. Do not take pyrimethamine without first talking to your doctor if you are pregnant or could become pregnant during treatment.
Pyrimethamine passes into breast milk and may be harmful to a nursing infant. Do not take pyrimethamine without first talking to your doctor if you are breast-feeding a baby.
There are no restrictions on foods, beverages, or activities during treatment with pyrimethamine unless otherwise directed by your doctor.
Seek emergency medical attention.
Symptoms of a pyrimethamine overdose may include abdominal pain, nausea, severe vomiting (possibly with blood in the vomit), anxiety or excitability, and seizures.
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose of the medication.
Stop taking pyrimethamine and seek emergency medical attention if you experience an allergic reaction (swelling of the lips, tongue, or face; difficulty breathing; closing of the throat; or hives) during treatment with pyrimethamine.
Stop taking pyrimethamine and seek medical attention at the first sign of a skin rash, sore throat, paleness of the skin, unusual bruising under the skin, or swelling of the tongue. These may be early symptoms of serious side effects of pyrimethamine.
Other, less serious side effects may be more likely to occur. Continue to take pyrimethamine and talk to your doctor if you experience
- nausea, vomiting, or loss of appetite;
- lightheadedness; or
- dryness of the mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Before taking pyrimethamine, tell your doctor if you are taking any of the following medicines:
- auranofin (Ridaura);
- aurothioglucose (Solganal); or
- or gold sodium thiomalate (Aurolate, Myochrysine).
You may not be able to take pyrimethamine, or you may require a dosage adjustment or special monitoring during treatment.
Drugs other than those listed here may also interact with pyrimethamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.
Daraprim and pyrimethamine
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Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04