What is dextroamphetamine?

Dextroamphetamine is a central nervous system stimulant. It affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control.

Dextroamphetamine is used to treat narcolepsy and attention deficit hyperactivity disorder (ADHD).

Dextroamphetamine may also be used for other purposes not listed in this medication guide.

Precautions

Do not use dextroamphetamine if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take dextroamphetamine before the MAO inhibitor has cleared from your body.

Do not use this medication if you are allergic to dextroamphetamine or if you have:

  • heart disease or moderate to severe high blood pressure (hypertension);
  • arteriosclerosis (hardening of the arteries);
  • overactive thyroid;
  • glaucoma;
  • severe anxiety, tension, or agitation; or
  • if you have a history of drug or alcohol addiction.

Some stimulants have caused sudden death in children and adolescents with serious heart problems or congenital heart defects. Before taking dextroamphetamine, tell your doctor if you have:

  • a congenital heart defect;
  • high blood pressure;
  • heart failure, heart rhythm disorder, or recent heart attack;
  • a personal or family history of mental illness, psychotic disorder, bipolar illness, depression, or suicide attempt;
  • epilepsy or other seizure disorder;
  • an allergy to dyes used in drugs or manufactured foods; or
  • tics (muscle twitches) or Tourette's syndrome.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Dextroamphetamine may cause premature birth, low birth weight, or withdrawal symptoms in a newborn if the mother takes dextroamphetamine during pregnancy. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

Dextroamphetamine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Long-term use of dextroamphetamine can slow a child’s growth. Tell your doctor if the child using this medication is not growing or gaining weight properly.

Do not give this medication to a child younger than 3 years old without the advice of a doctor.

Dextroamphetamine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Do not take dextroamphetamine late in the day. A dose taken too late in the day can cause sleep problems (insomnia).

Avoid drinking fruit juices or taking vitamin C at the same time you take dextroamphetamine. These can make your body absorb less of the medicine.

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Instructions

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of dextroamphetamine can be fatal.

Overdose symptoms may include restlessness, tremor, muscle twitches, rapid breathing, confusion, hallucinations, panic, aggressiveness, muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine. These symptoms may be followed by depression and tiredness. Other overdose symptoms include nausea, vomiting, diarrhea, stomach pain, uneven heartbeats, feeling light-headed, fainting, seizure (convulsions), or coma.

Take the missed dose as soon as you remember. If it is almost time for your next dose, or if it is already evening, skip the missed dose and take the medicine the next morning. Taking this medicine late in the day can cause sleep problems. Do not take extra medicine to make up the missed dose.

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Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using dextroamphetamine and call your doctor at once if you have any of these serious side effects:

  • fast or pounding heartbeats;
  • feeling light-headed, fainting;
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure); or
  • tremor, restlessness, hallucinations, unusual behavior, or motor tics (muscle twitches).

Less serious side effects may include:

  • headache or dizziness;
  • sleep problems (insomnia);
  • dry mouth or an unpleasant taste in your mouth;
  • diarrhea, constipation;
  • loss of appetite, weight loss; or
  • loss of interest in sex, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Interactions

Before taking dextroamphetamine, tell your doctor if you are using any of the following drugs:

  • blood pressure medications;
  • a diuretic (water pill);
  • cold or allergy medicines (antihistamines);
  • acetazolamide (Diamox);
  • chlorpromazine (Thorazine);
  • ethosuximide (Zarontin);
  • guanethidine (Ismelin);
  • haloperidol (Haldol);
  • lithium (Eskalith, Lithobid);
  • methenamine (Hiprex, Mandelamine, Urex);
  • phenytoin (Dilantin), phenobarbital (Luminal, Solfoton);
  • propoxyphene (Darvon, Darvocet);
  • reserpine;
  • sodium bicarbonate (Alka-Seltzer); or
  • an antidepressant such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), or nortriptyline (Pamelor).

This list is not complete and there may be other drugs that can interact with dextroamphetamine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

Dexedrine Spansule, dextroamphetamine, Dexedrine, Dextrostat, and ProCentra

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Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

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