Sirolimus may increase your risk of developing lymphoma or other forms of cancer. Talk with your doctor about your specific cancer risk.
You should not use this medication if you are allergic to sirolimus.
If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take sirolimus, tell your doctor if you are allergic to any drugs, or if you have:
- high cholesterol or triglycerides;
- cytomegalovirus (CMV);
- liver disease; or
- kidney disease.
FDA pregnancy category C. It is not known whether sirolimus is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Use an effective form of birth control while you are using this medication and for at least 12 weeks after your treatment ends.
It is not known whether sirolimus passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
This medicine should not be given to a child younger than 13 years old.
Grapefruit and grapefruit juice may interact with sirolimus and could lead to potentially dangerous effects. Do not mix this medicine with grapefruit juice. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus.
Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection.
Do not receive a vaccine while you are being treated with sirolimus. The vaccine may not work as well during this time, and may not fully protect you from disease.
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Sirolimus may increase your risk of skin cancer. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a sirolimus overdose are not known but may include some of the side effects listed in this medication guide.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- fast heart rate;
- pain when you breathe, feeling short of breath;
- chest pain, feeling weak or tired;
- coughing up blood or mucus;
- feeling like you might pass out;
- pale skin, easy bruising or bleeding, weakness;
- fever, chills, body aches, flu symptoms;
- night sweats, weight loss;
- swelling in your face, stomach, hands or feet;
- rapid weight gain;
- pain or burning when you urinate; or
- slow healing of a wound.
Less serious side effects may include:
- joint pain;
- nausea, vomiting, diarrhea, constipation, stomach pain;
- headache; or
- acne or skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor if you are using any of the following drugs:
- amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet);
- bromocriptine (Parlodel);
- cimetidine (Tagamet);
- cisapride (Propulsid);
- danazol (Danocrine);
- metoclopramide (Reglan );
- rifampin (Rifater, Rifadin, Rimactane), rifabutin (Mycobutin), rifapentine (Priftin);
- St. John's wort;
- tacrolimus (Prograf);
- an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik);
- an antibiotic such clarithromycin (Biaxin), erythromycin (E-Mycin, Ery-Tab, Erythrocin, E.E.S), telithromycin (Ketek), capreomycin (Capastat), or troleandomycin (Tao);
- an antifungal medication such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
- a calcium channel blocker such as diltiazem (Tiazac, Cardizem), nicardipine (Cardene), or verapamil (Calan, Covera, Verelan);
- HIV medicines such as indinavir (Crixivan) or ritonavir (Norvir); or
- seizure medicine such as carbamazepine (Tegretol), phenytoin (Dilantin), phenobarbital (Luminal).
This list is not complete and there may be other drugs that can interact with sirolimus. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Rapamune and sirolimus
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Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04