Effects both positive and adverse, both expected and unexpected, are pretty noticeable. Venlafaxine effects appear and fade much more rapidly than with SSRIs, and may change over time. By the time I stopped, I had been down to the lowest available dose of 25mg daily, which still seemed necessary for mood control, for a long time. It's been mostly helpful, and rarely burdensome except for the way it multiplies the effects of alcohol.
Best unexpected benefit: mood control (less panicky/angry responses to cognitive dissonance).
Intolerable imputed effect: Vividly unpleasant dreams, waking hyperventilating.
Cost
< $25 monthly
Date
Mar 01, 2010
Advice & Tips
Adverse effects now virtually disappear for me at 25 mg daily. This could change: some effects like the pounding in the ears at night or postural hypotension had previously disappeared at 37.5 mg; alarmingly rapid heart rate appeared over time at the same dosage (possibly associated with the transient hypotension). I'm still getting the good effects for the neuropathy, and the drug seems to act synergetically with cannabis in this area. The hypotension effect is probably aggravated by alcohol.
Cost
< $25 monthly
Date
Nov 13, 2009
Advice & Tips
Venlaxafine seemed effective (within limits) for peripheral neuropathy and positive for relief of depression. Physical adverse effects at this dosage seemed minimal if any. Unresolved: Did this drug bliss me out too much, keeping me passive and lazy? And did it make me more suddenly irritable? I quit because of a pharmacy restriction (ironically based on the fact that I was taking "too little" of the drug), and will resume the trial once I talk to my primary provider in about 10 days.
Cost
< $25 monthly
Date
Oct 28, 2009
Advice & Tips
Venlafaxine by itself seems both to increase my alertness and to bliss me out a little too much; I get lethargic at 75 mg daily. Even at 37.5 mg, I've added (after a bit of research) my previous low dose of bupropion (25 mg) back into the mix as a counterbalancing "upper". Although intermittent, I'm seeing some direct effects on the depression: e.g., posture as well as mood.
I would have kept taking Effexor if could, despite not being effective for anxiety, because I had no appetite and could have easily lost weight, but the sleepiness was too severe.
I am no longer taking Effexor due to overwhelming side effects for me. It did a great job dialing down the fibro pain, but made me too crazy to continue with it.
Cost
< $25 monthly
Date
Mar 13, 2012
Advice & Tips
Really works on FM pain, but beware the side effects...it left me very depressed, thinking about suicide, made it hard to think logically (or at all, for that matter); I would highly recommend trying it, because it really does knock out most of the FM pain, just watch the side effects.
Cost
< $25 monthly
Date
Mar 07, 2012
Advice & Tips
Currently in the process of stepping off Effexor and back onto Paxil; side effects were too severe;
Only positive side effect was relaxed inhibitions during counseling sessions