I have been using Avonex since the original Trials...many years ago (around 1990), and have never missed a dose! I really believe it has had a LOT to do with my MS not progressing as quickly.
The shots are really no big deal. And, now you can use a shorter needle! yea!
After all these years, my biggest problem is trying to find new spots to inject! (Don't want to damage tissue)_