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What is Modafinil?

Modafinil is stimulant used to improve wakefulness in patients narcolepsy and shift work sleep disorder; adjunctive therapy for obstructive sleep apnea. Off label it is used for attention-deficit/hyperactivity disorder and to treat fatigue in MS and other disorders.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose # of patients
# of patients with evaluations Efficacy
Major
Moderate
Slight
None
Can’t tell
Fatigue 1335 362 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
MS (Multiple Sclerosis) 682 62 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Excessive daytime sleepiness (somnolence) 351 119 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Brain fog 80 26 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Other 50 11 Efficacy_major Efficacy_moderate Efficacy_slight
Cognitive impairment 34 9 Efficacy_major Efficacy_moderate Efficacy_slight

See all 1664 patients currently taking Modafinil

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Reported Side Effects

Side effects as an overall problem

Severe
 34
Moderate
 76
Mild
 134
None
 281

Commonly reported side effects, conditions, and hospitalizations associated with Modafinil

Jittery feeling 51
Dry mouth (xerostomia) 48
Headaches 37
Sleep problems 30
Anxious mood 30
Heart rate increased 26
See all 102 reported side effects ▼ See top 6 reported side effects ▲

Reported Dosages

Frequently reported dosages based on patients currently taking Modafinil. See all 52 dosages ►

  50mg as needed 2 100mg as needed 100mg as needed daily 200mg as needed 50 mg daily 100 mg daily 200 mg daily 300 mg daily 400 mg daily
  10 Number of Patients: 10 11 Number of Patients: 11 89 Number of Patients: 89 21 Number of Patients: 21 62 Number of Patients: 62 17 Number of Patients: 17 376 Number of Patients: 376 716 Number of Patients: 716 36 Number of Patients: 36 266 Number of Patients: 266  

Reported Stop Reasons

Why Patients Stopped Taking Modafinil (multiple reasons could be selected)
Reason # Patients Percentage of patients
Did not seem to work 210   Did not seem to work: 31%
Other 152   Other: 22%
Expense 151   Expense: 22%
Side effects too severe 140   Side effects too severe: 21%
Doctor's advice 86   Doctor's advice: 13%
Change in health plan coverage 66   Change in health plan coverage: 10%
Personal research 29   Personal research: 4%
Course of treatment ended 14   Course of treatment ended: 2%
Not indicated 6   Not indicated: 1%

See all 658 patients who’ve stopped taking Modafinil

Reported Duration See details about how long patients take this treatment ▼

Currently Taking Modafinil

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Stopped Taking Modafinil

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations ▼

Adherence

Taking treatment as prescribed

Adherence of Modafinil

Always
 339 65%
Usually
 123 23%
Sometimes
 46 9%
Never
 17 3%

Burden

Difficulty being on treatment

Burden of Modafinil

Very
 23 4%
Somewhat
 39 7%
A little
 68 13%
Not at all
 395 75%

Cost

Paid out of pocket

Cost of Modafinil

$200+
 39 10%
$100-199
 21 5%
$50-99
 82 21%
$25-49
 101 26%
< $25
 137 35%

See more information, including instructions, precautions, side effects, and interactions.

Report created on May 28, 2012.