What is Duloxetine?
Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It is used for depression, general anxiety disorder, pain associated with diabetic neuropathy and for fibromyalgia.
Reported Side Effects
Side effects
as an overall problem
Commonly reported side effects, conditions, and hospitalizations associated with Duloxetine
|
Nausea
|
128 |
|
|
Sex drive (libido) decreased
|
116 |
|
|
Sweating increased
|
96 |
|
|
Dizziness
|
95 |
|
|
Weight gain
|
80 |
|
|
Insomnia
|
74 |
|
|
Brain cloud
|
72 |
|
|
Feel flat
|
58 |
|
|
Dry mouth (xerostomia)
|
57 |
|
|
Constipation
|
43 |
|
|
Sedation
|
41 |
|
|
Sweating excessive
|
30 |
|
|
Difficulty with orgasm
|
26 |
|
|
Fatigue
|
20 |
|
|
Mania
|
19 |
|
|
Drowsiness
|
15 |
|
|
Headaches
|
15 |
|
|
Sexual dysfunction
|
15 |
|
|
Hospitalization
|
14 |
|
|
Excessive daytime sleepiness (somnolence)
|
13 |
|
|
Migraine headaches
|
12 |
|
|
Brain zaps
|
12 |
|
|
Loss of appetite
|
12 |
|
|
Night sweats
|
11 |
|
|
Nausea and vomiting
|
10 |
|
|
Anxious mood
|
10 |
|
|
Hot flashes
|
9 |
|
|
Tiredness
|
9 |
|
|
Difficulty sleeping through night
|
8 |
|
|
Mood swings
|
8 |
|
|
Loss of sex drive (libido)
|
8 |
|
|
Depressed mood
|
8 |
|
|
Brain fog
|
8 |
|
|
Dry throat
|
8 |
|
|
Blurry vision
|
8 |
|
|
Depression with suicidal thoughts
|
7 |
|
|
Decreased appetite
|
7 |
|
|
Restless feeling in legs
|
7 |
|
|
Sleepiness
|
7 |
|
|
Suicidal thoughts or urges
|
7 |
|
|
Elevated blood pressure
|
7 |
|
|
Stomach pain
|
6 |
|
|
Excessive dry mouth
|
6 |
|
|
Stomach upset
|
6 |
|
|
Daytime sleepiness
|
6 |
|
|
Diarrhea
|
6 |
|
|
Vivid dreams
|
6 |
|
|
Heart palpitations
|
5 |
|
|
Excessive yawning
|
5 |
|
|
Frequent vertigo with nausea
|
5 |
|
|
Frequent nausea
|
5 |
|
|
Emotional numbness or flatness
|
4 |
|
|
Urinary hesitancy
|
4 |
|
|
Rashes (redness, swelling)
|
4 |
|
|
Sweating
|
4 |
|
|
Hyperactivity
|
4 |
|
|
Serotonin syndrome
|
4 |
|
|
Ringing in ears (tinnitus)
|
4 |
|
|
Dry eyes
|
4 |
|
|
Exhaustion
|
4 |
|
|
Weight loss
|
4 |
|
|
Jittery feeling
|
4 |
|
|
Vomiting
|
4 |
|
|
Ejaculation delayed
|
3 |
|
|
Itching (pruritus)
|
3 |
|
|
Bruising
|
3 |
|
|
Muscle twitching (fasciculations)
|
3 |
|
|
Panic attacks
|
3 |
|
|
Suicidal
|
3 |
|
|
Nightmares
|
3 |
|
|
Pain in lower back
|
3 |
|
|
Increased appetite
|
3 |
|
|
Withdrawal effects
|
3 |
|
|
Difficulty urinating occasionally
|
3 |
|
|
Increased fatigue
|
3 |
|
|
Dizziness (vertigo)
|
3 |
|
|
Muscle spasms
|
3 |
|
|
Swelling in legs, feet and ankles
|
3 |
|
|
Unrefreshing or poor sleep
|
3 |
|
|
Dizziness with nausea
|
3 |
|
|
Depression with anxiety
|
3 |
|
|
SSRI Discontinuation (withdrawal) Syndrome
|
3 |
|
|
Excessive sleeping (hypersomnia)
|
3 |
|
|
Increased or worsened depression
|
3 |
|
|
Increased insomnia
|
3 |
|
|
Hallucinations
|
3 |
|
|
No sexual desire
|
3 |
|
|
Tremor in hands
|
2 |
|
|
Bowel irritability
|
2 |
|
|
Problems with focusing eyes
|
2 |
|
|
Chronic constipation
|
2 |
|
|
Edema (fluid retention)
|
2 |
|
|
Apathy
|
2 |
|
|
Constant tremors
|
2 |
|
|
Urinary retention
|
2 |
|
|
Aggression
|
2 |
|
|
Poor Concentration
|
2 |
|
|
Bloating
|
2 |
|
|
Anxiety attacks
|
2 |
|
|
Listlessness
|
2 |
|
|
Chest tightness
|
2 |
|
|
None
|
2 |
|
|
Electric shock sensations
|
2 |
|
|
Deadened emotions
|
2 |
|
|
Irritability
|
2 |
|
|
Constipation with occasional impaction
|
2 |
|
|
Antidepressant withdrawal syndrome
|
2 |
|
|
Shakiness
|
2 |
|
|
Allergic reaction
|
2 |
|
|
Pain
|
2 |
|
|
Hypomania
|
2 |
|
|
Abdominal bloating
|
2 |
|
|
Somnolence
|
2 |
|
|
Heartburn
|
2 |
|
|
Feeling of disconnection
|
2 |
|
|
Loss of balance
|
2 |
|
|
Acid reflux
|
2 |
|
|
Fluid retention weight gain
|
2 |
|
|
Dizziness and feeling faint
|
2 |
|
|
Bruxism (teeth grinding)
|
2 |
|
|
Shortness of breath (dyspnea)
|
2 |
|
|
Suicidal ideation
|
2 |
|
|
Craving sweets sugar
|
2 |
|
|
Side effects when dose skipped
|
2 |
|
|
Nervousness
|
2 |
|
|
Anger
|
2 |
|
|
Tachycardia (fast heart rate)
|
2 |
|
|
Feeling hot
|
2 |
|
|
Seizures (grand mal or tonic-clonic)
|
2 |
|
|
Anxiety and frustration
|
2 |
|
|
Fever
|
2 |
|
|
Shaky hands
|
2 |
|
|
Elevated liver enzymes
|
2 |
|
|
Heart rate increased
|
2 |
|
|
Sex drive (libido) increased
|
2 |
|
|
Agitation with irritability
|
2 |
|
|
Loss of energy
|
2 |
|
|
Mood changes
|
2 |
|
|
Joint pain
|
2 |
|
|
Mood elevated or improved
|
1 |
|
|
Swelling in ankle
|
1 |
|
|
Loose stools
|
1 |
|
|
Thirst
|
1 |
|
|
Skin rash
|
1 |
|
|
Bad taste in mouth
|
1 |
|
|
Appetite change
|
1 |
|
|
Flu like symptoms
|
1 |
|
|
Diarrhea during titration
|
1 |
|
|
Compulsive scratching
|
1 |
|
|
Memory problems
|
1 |
|
|
Overeating
|
1 |
|
|
worsening of symptoms
|
1 |
|
|
Laziness
|
1 |
|
|
Sleep problems
|
1 |
|
|
Gas
|
1 |
|
|
Crying spells
|
1 |
|
|
"Lucite Encased" Head
|
1 |
|
|
Impatient
|
1 |
|
|
Flatulence
|
1 |
|
|
Apathy to environment
|
1 |
|
|
Slowed thinking
|
1 |
|
|
Feeling worthless
|
1 |
|
|
Sporadic electric shock sensations in legs
|
1 |
|
|
Loose bowel movements
|
1 |
|
|
Sudden blasts of hunger
|
1 |
|
|
Occassional jittery feeling
|
1 |
|
|
Dark, soft stools
|
1 |
|
|
Major Depressive Disorder
|
1 |
|
|
Spasms
|
1 |
|
|
Raised body temperature
|
1 |
|
|
Sensitivity to sudden loud noises
|
1 |
|
|
Bowel problems
|
1 |
|
|
Muscle and joint pain
|
1 |
|
|
Bladder problems
|
1 |
|
|
IBS (Irritable Bowel Syndrome)
|
1 |
|
|
Hoarseness of voice
|
1 |
|
|
Cold intolerance
|
1 |
|
|
Spaced out
|
1 |
|
|
Inability to handle stress (bad stress reactions)
|
1 |
|
|
Overwhelming emotions
|
1 |
|
|
Itchy scalp
|
1 |
|
|
Hypertension
|
1 |
|
|
Feeling of insides shaking
|
1 |
|
|
Bleeding (hemorrhage)
|
1 |
|
|
Mental confusion
|
1 |
|
|
Spinning dizziness (vertigo)
|
1 |
|
|
Absence of menstruation (amenorrhea)
|
1 |
|
|
Withdrawal effects with missed dose
|
1 |
|
|
Parkinsonism
|
1 |
|
|
Cramps in calf muscles
|
1 |
|
|
Swelling in hands
|
1 |
|
|
strange ideas
|
1 |
|
|
Body odor
|
1 |
|
|
Bruise easily
|
1 |
|
|
sometimes wake up more sleepy then when I laid down
|
1 |
|
|
dilated pupils
|
1 |
|
|
Outburst of anger
|
1 |
|
|
Urine smell abnormal
|
1 |
|
|
Tremor in right thumb
|
1 |
|
|
Diarrhea while sleeping
|
1 |
|
|
Drug dependence
|
1 |
|
|
Feeling out of it
|
1 |
|
|
Irregular menstrual periods
|
1 |
|
|
Seizure with staring episodes
|
1 |
|
|
Burning mouth syndrome
|
1 |
|
|
Feeling sick
|
1 |
|
|
muscle pain, legs, tendons, ankles, hands, wrist and lower arms
|
1 |
|
|
Anticipatory anxiety
|
1 |
|
|
Stimulant - interferes with sleep
|
1 |
|
|
Loss of sleep
|
1 |
|
|
Electric shock sensations in brain
|
1 |
|
|
Weird or strange dreams
|
1 |
|
|
Meniere's Disease
|
1 |
|
|
Drenching sweats during flares
|
1 |
|
|
Uro-Genital Syndrome
|
1 |
|
|
Blood in stool
|
1 |
|
|
Dry mouth at night
|
1 |
|
|
saw bugs
|
1 |
|
|
Liver damage
|
1 |
|
|
Increased urination
|
1 |
|
|
Pain worsened
|
1 |
|
|
Body Twitches
|
1 |
|
|
Sensitivity to medications
|
1 |
|
|
Pressure headaches
|
1 |
|
|
Weakness in legs
|
1 |
|
|
Generalized itching
|
1 |
|
|
Cold sweat
|
1 |
|
|
Spinal Stenosis
|
1 |
|
|
Chronic Headache Disorder
|
1 |
|
|
Increased urinary frequency
|
1 |
|
|
eye sight is getting worse and not because of age.
|
1 |
|
|
Whole body shaking
|
1 |
|
|
Episodic disorientation
|
1 |
|
|
Horrifying nightmares
|
1 |
|
|
Adrenaline Rush
|
1 |
|
|
Stomach problems
|
1 |
|
|
Dark urine
|
1 |
|
|
Funny feeling in head.
|
1 |
|
|
Injection site irritation
|
1 |
|
|
Vivid Nightmares
|
1 |
|
|
Subjective tinnitus (clicking beating noise and pulsations in the ear)
|
1 |
|
|
Primary Insomnia
|
1 |
|
|
Chronic Hyperglycemia
|
1 |
|
|
Anorexia (appetite loss)
|
1 |
|
|
Vertigo
|
1 |
|
|
Increased anxiety
|
1 |
|
|
Swollen lips
|
1 |
|
|
Joints ache (whole body)
|
1 |
|
|
Dyspepsia
|
1 |
|
|
Tremor
|
1 |
|
|
Drowsy in a.m.
|
1 |
|
|
Wakefulness
|
1 |
|
|
Difficulty urinating (dysuria)
|
1 |
|
|
Occasional euphoria
|
1 |
|
|
Liver pain
|
1 |
|
|
Fuzzy thinking
|
1 |
|
|
Sexual impotence
|
1 |
|
|
Eye pressure
|
1 |
|
|
Swelling of throat
|
1 |
|
|
Internal tremor
|
1 |
|
|
insomnia, agitation, & anxiety when stopping treatment
|
1 |
|
|
Bad mood
|
1 |
|
|
Electric shock in face
|
1 |
|
|
Hot and cold flashes
|
1 |
|
|
over heating, to the point of chest tighting and forced to not move
|
1 |
|
|
weight gain,swelling in spinal area ,hands and feet
|
1 |
|
|
Daytime tiredness
|
1 |
|
|
Insomnia agitation
|
1 |
|
|
Not interested in sex
|
1 |
|
|
at first very sleepy not now though
|
1 |
|
|
Dizziness with disorientation
|
1 |
|
|
not sure if it's affecting my memory and or response time or if that is medical problem
|
1 |
|
|
Don't remember
|
1 |
|
|
Breakthrough intermenstrual bleeding
|
1 |
|
|
Accidental Fall
|
1 |
|
|
triggered rapid cycling, suicide attempt
|
1 |
|
|
tired, nonchalant attitude.
|
1 |
|
|
some relief in pain and depression
|
1 |
|
|
Thick head
|
1 |
|
|
Uncontrollable shaking
|
1 |
|
|
Male sexual dysfunction
|
1 |
|
|
Alternating constipation and diarrhea
|
1 |
|
|
Increased thirst
|
1 |
|
|
Sick to my stomach
|
1 |
|
|
Body Tingling
|
1 |
|
|
Heavy sweating anytime, day or night
|
1 |
|
|
spiking blood pressure
|
1 |
|
|
thick head & flat mood
|
1 |
|
|
Dizziness/walking like I'm drunk
|
1 |
|
|
disequalibrium
|
1 |
|
|
Oversleeping (too much sleep)
|
1 |
|
|
Tired legs
|
1 |
|
|
sleepy-loopy
|
1 |
|
|
legs seemed to be paralyzed for a minute
|
1 |
|
|
Stomach ache
|
1 |
|
|
Bladder pain
|
1 |
|
|
Dry tongue
|
1 |
|
|
Generalized weakness (asthenia)
|
1 |
|
|
Occasional nausea and vomiting
|
1 |
|
|
Feeling strange
|
1 |
|
|
Buzzing Sensation of Body
|
1 |
|
|
Constant vomiting
|
1 |
|
|
when you can't afford to stay on them its not as effective
|
1 |
|
|
Loss of coordination
|
1 |
|
|
stabbing and swelling pain stomach yellow bowel movements muddy pain
|
1 |
|
|
Overstimulated
|
1 |
|
|
noise in head
|
1 |
|
|
Headaches all day
|
1 |
|
|
Urinary Tract Infection UTI
|
1 |
|
|
Burning sensation in back
|
1 |
|
|
Hand twitches
|
1 |
|
|
Nerve pain (neuralgia)
|
1 |
|
|
Pins and needles
|
1 |
|
|
Sore throat (Pharyngitis)
|
1 |
|
|
Lose train of thought
|
1 |
|
|
Sneezing
|
1 |
|
|
Agitation
|
1 |
|
|
Binge eating in evening
|
1 |
|
|
Anxiety with missed dose
|
1 |
|
|
Sleeplessness for first month
|
1 |
|
|
Loss of short term memory
|
1 |
|
|
hard to control blood sugars
|
1 |
|
|
Feelings of hopelessness
|
1 |
|
|
Dissociation
|
1 |
|
|
Word fishing
|
1 |
|
|
Kidney stones
|
1 |
|
|
Hives (urticaria)
|
1 |
|
|
Feeling of lump in throat
|
1 |
|
|
Eye Twitching
|
1 |
|
|
Tension headaches
|
1 |
|
|
Muscle fatigue
|
1 |
|
|
Self harm thoughts or urges
|
1 |
|
|
Menstrual cramps
|
1 |
|
|
Preoccupation with food
|
1 |
|
|
Neck pain
|
1 |
|
|
Urinary tract pain
|
1 |
|
|
Acne
|
1 |
|
|
Sadness
|
1 |
|
|
Confusion
|
1 |
|
|
Lightheadedness
|
1 |
|
|
Cough
|
1 |
|
|
Rash or skin problems
|
1 |
|
|
Narrow (closed) angle glaucoma right eye
|
1 |
|
|
Dizziness with hypotension upon standing
|
1 |
|
|
Chills/fever
|
1 |
|
|
Inability to experience pleasure (anhedonia)
|
1 |
|
|
Frustration
|
1 |
|
|
Restlessness
|
1 |
|
|
An overall crappy feeling all the time
|
1 |
|
|
Menstruation differences
|
1 |
|
|
Crying for good reason
|
1 |
|
|
Orthostatic/Postural Hypotension
|
1 |
|
|
Double vision (diplopia)
|
1 |
|
|
Crawling sensations in skin
|
1 |
|
|
flat affect
|
1 |
|
|
Tightness in hands
|
1 |
|
|
Bipolar rapid cycling
|
1 |
|
|
Heart palpitations then feel faint
|
1 |
|
|
Cold and clammy
|
1 |
|
|
Cognitive Confusion
|
1 |
|
|
Paresthesia
|
1 |
|
|
Tightness in throat and neck area
|
1 |
|
|
Memory lapses (brain blinks)
|
1 |
|
|
Heat intolerance
|
1 |
|
|
Jumpy feeling
|
1 |
|
|
Extreme sedation
|
1 |
|
|
Incontinence
|
1 |
|
|
Vision difficulty
|
1 |
|
|
Numbness and Tingling with Pins and Needles
|
1 |
|
|
Increased Hunger
|
1 |
|
|
Visual hallucinations
|
1 |
|
|
Sjogrens syndrome
|
1 |
|
|
Chills
|
1 |
|
|
See all
373 reported side effects
▼
See top
6 reported side effects
▲
|
Currently Taking Duloxetine
A bar graph
Stopped Taking Duloxetine
A bar graph
Adherence
Taking treatment as prescribed
Adherence of Duloxetine
Always |
1244
|
85%
|
|
Usually |
142
|
10%
|
|
Sometimes |
16
|
1%
|
|
Never |
58
|
4%
|
|
Burden
Difficulty being on treatment
Burden of Duloxetine
Cost
Paid out of pocket
Cost of Duloxetine
$200+ |
28
|
3%
|
|
$100-199 |
83
|
8%
|
|
$50-99 |
186
|
19%
|
|
$25-49 |
296
|
30%
|
|
< $25 |
398
|
40%
|
|
See more information,
including instructions, precautions, side effects, and interactions.
