I am a male age 49. I have a wonderful,supportive wife, 3 kids, and 2 grandchildren. I adore them all. I am the third member of my family to have ALS. My mother and brother both lived 5 years after their diagnosis. The family has the familial sod1 strain. I just finished a 4 month trial by TDI. I am taking 100 mg a day.My dosage started at 12.5mg and went up slightly from there until i reached 100mg I am very encouraged by my reactions to this medicine. I have a family history that should give me very reliable tract on how this drug is working.