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What is Tolcapone?

Tolcapone is a COMT inhibitor which promotes the recirculation of dopamine at the synapse. It is used in conjunction with l-dopa containing medication such as Sinemet.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose # of patients
# of patients with evaluations Efficacy
Major
Moderate
Slight
None
Can’t tell
Parkinson's Disease 14 4 Efficacy_major Efficacy_moderate Efficacy_cant_tell
adds time of carb/levo dose. gives me 2 extra hours 2 1 Efficacy_slight
Other 1 1 Efficacy_major
Increase effect of another treatment 1 1 Efficacy_major

See all 16 patients currently taking Tolcapone

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Reported Side Effects

Side effects as an overall problem

Severe
 2
Moderate
 0
Mild
 0
None
 3

Commonly reported side effects, conditions, and hospitalizations associated with Tolcapone

Insomnia 1
Constipation 1
Pain 1
Dizziness 1
Diarrhea 1
Urinary retention 1
See all 20 reported side effects ▼ See top 6 reported side effects ▲

Reported Dosages

  100 mg daily 200 mg daily 300 mg daily 400 mg daily 600 mg daily
  1 Number of Patients: 1 3 Number of Patients: 3 9 Number of Patients: 9 1 Number of Patients: 1 2 Number of Patients: 2  

Reported Stop Reasons

Why Patients Stopped Taking Tolcapone (multiple reasons could be selected)
Reason # Patients Percentage of patients
Side effects too severe 2   Side effects too severe: 100%
Did not seem to work 1   Did not seem to work: 50%
Expense 1   Expense: 50%
Personal research 1   Personal research: 50%

See all 2 patients who’ve stopped taking Tolcapone

Reported Duration See details about how long patients take this treatment ▼

Currently Taking Tolcapone

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
0
0
0
0

Stopped Taking Tolcapone

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
0
0
0
0
0

Reported Adherence, Burden & Cost See details from patient evaluations ▼

Adherence

Taking treatment as prescribed

Adherence of Tolcapone

Always
 4 80%
Usually
 1 20%
Sometimes
 0 0%
Never
 0 0%

Burden

Difficulty being on treatment

Burden of Tolcapone

Very
 1 20%
Somewhat
 0 0%
A little
 0 0%
Not at all
 4 80%

Cost

Paid out of pocket

Cost of Tolcapone

$200+
 1 25%
$100-199
 0 0%
$50-99
 2 50%
$25-49
 1 25%
< $25
 0 0%

See more information, including instructions, precautions, side effects, and interactions.

Report created on February 11, 2012.