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What is Carbidopa-Entacapone-Levodopa?

The combination of levodopa, carbidopa, and entacapone is used for Parkinson's Disease. Levodopa is the precursor to dopamine, carbidopa slows the breakdown of levodopa, while entacapone improves the efficacy of levodopa.

Reasons taken & Efficacy

Reasons and Efficacy
Reasons taken	# of patients Efficacy	# of patients evaluated by
Parkinson's Disease PD	261	71
Stiffness/Spasticity	11	2
Other	10	2
Support another treatment	7	1
Mobility	5	1
Parkinsonism	3	0
disease-related symptoms	2	0
Slowness	2	0
tremor in hands	2	0
Foot dystonia	2	0
on/off	2	2
Suspected DRD	1	0
balance became worse	1	0
bad reaction	1	0
General health	1	0
level out dyskinesia	1	0
Slurred speech	1	0
Tremor	1	0
Don't know	1	0
Assistive communication	1	0
leg cramping	1	0
Brain fog	1	0
Tremor in hands	1	0
5times daily	1	1
Memory problems	1	0
Stiffness	1	0

See all 26 reasons taken ▼

See all 328 patients currently taking Carbidopa-Entacapone-Levodopa

Mouse over the table for more information

Side Effects

Side effects as an overall problem

Severe	8	10%
Moderate	16	21%
Mild	24	31%
None	29	38%

Most commonly reported side effects

Dyskinesia	14	29%	7 8 2
Wearing off leg cramps	9	19%	4 6 2
Wearing off increased tremors	8	17%	4 5 1
Nausea	8	17%	6 1 1
Fatigue	5	10%	2 2 2
Weight gain	5	10%	2 2 1
Urinary retention	4	8%	3 1 2
Urine amber color	4	8%
Vision distortion	3	6%
Insomnia	3	6%
Emotional cycling	3	6%
Cognitive Confusion	3	6%
Dizziness (vertigo)	2	4%
involentary movements	2	4%
Diarrhea	2	4%
headache, insomnia	1	2%
Stiff neck	1	2%
Tremor	1	2%
High blood pressure (Hypertension)	1	2%
involuntary movment	1	2%
Stomach pain	1	2%
dry mouth,tongue	1	2%
LID Levodopa-Induced Dyskiinesia	1	2%
desiquilibrio	1	2%
Rapid, shallow breathing	1	2%
Disordered muscle tension (dystonia)	1	2%
Itching (pruritus)	1	2%
Stiffness in jaw	1	2%
darker urination(stains underwear)	1	2%
Depression with suicidal thoughts	1	2%
psychotic symptoms mostly, anxiety depression a whole tons of fear	1	2%
diskynesia	1	2%
Jaw disjointed	1	2%
hyperkinsesia	1	2%
Confusion	1	2%
WIRED	1	2%
chest tightness-breathing difficulty	1	2%
Numbness in toes	1	2%
unusual taste	1	2%
Vomiting	1	2%
Jerky movements (dyskinesia)	1	2%

Mild
Moderate
Severe

See all 41 reported side effects ▼

Dosages

Top 10 dosages based on patients currently taking Carbidopa-Entacapone-Levodopa. See all 68 dosages ►

100 mg all the time (24/7)	100mg as needed	25 mg-200 mg-100 mg all the time (24/7)	25 mg-200 mg-100 mg daily	daily	0.05 mg daily	3 mg daily	3 other daily	4 mg daily	4 other daily	5 intl units daily	6 mg daily	6 other daily	25 mg daily	12.5 mg-200 mg-50 mg daily	50 mg daily	18.75 mg-200 mg-75 mg daily	75 mg daily	80 mg daily	100 mg daily	25 mg-200 mg-100 mg daily	2 x 12.5 mg-200 mg-50 mg daily	125 mg daily	31.25 mg-200 mg-125 mg daily	150 mg daily	150 other daily	37.5 mg-200 mg-150 mg daily	3 x 12.5 mg-200 mg-50 mg daily	200 mg daily	200 other daily	2 x 25 mg-200 mg-100 mg daily	4 x 12.5 mg-200 mg-50 mg daily	3 x 18.75 mg-200 mg-75 mg daily	250 mg daily	2 x 31.25 mg-200 mg-125 mg daily	5 x 12.5 mg-200 mg-50 mg daily	2 x 37.5 mg-200 mg-150 mg daily	300 mg daily	3 x 25 mg-200 mg-100 mg daily	6 x 12.5 mg-200 mg-50 mg daily	350 mg daily	7 x 12.5 mg-200 mg-50 mg daily	3 x 31.25 mg-200 mg-125 mg daily	400 mg daily	4 x 25 mg-200 mg-100 mg daily	8 x 12.5 mg-200 mg-50 mg daily	3 x 37.5 mg-200 mg-150 mg daily	450 mg daily	4 x 31.25 mg-200 mg-125 mg daily	500 mg daily	5 x 25 mg-200 mg-100 mg daily	3 x 50 mg-200 mg-200 mg daily	4 x 37.5 mg-200 mg-150 mg daily	600 mg daily	6 x 25 mg-200 mg-100 mg daily	625 mg daily	650 mg daily	700 mg daily	7 x 25 mg-200 mg-100 mg daily	5 x 37.5 mg-200 mg-150 mg daily	750 mg daily	800 mg daily	8 x 25 mg-200 mg-100 mg daily	6 x 37.5 mg-200 mg-150 mg daily	900 mg daily	5 x 50 mg-200 mg-200 mg daily	1200 mg daily	6 x 50 mg-200 mg-200 mg daily
1	1	1	1	12	1	2	2	6	1	1	1	1	1	1	4	1	3	1	13	13	5	1	1	8	1	6	9	12	2	4	14	1	1	1	5	1	22	29	3	1	1	1	14	30	1	12	6	4	4	13	2	14	12	5	1	1	2	1	10	3	3	2	5	3	1	1	1

Stop Reasons

Why Patients Stopped Taking Carbidopa-Entacapone-Levodopa (multiple reasons could be selected)
Reason	# Patients	Percentage of patients
Side effects too severe	26	34%
Doctor's advice	20	26%
Did not seem to work	14	18%
Expense	12	16%
Other	10	13%
Not indicated	6	8%
Personal research	3	4%

See all 74 patients who’ve stopped taking Carbidopa-Entacapone-Levodopa

Duration See details about how long patients take this treatment ▼ Duration Hide details ▲

Currently Taking Carbidopa-Entacapone-Levodopa

0-1 month	1-3 months	3-6 months	6 months-1year	1-2 years	2 years or more
3	5	13	28	41	70

Stopped Taking Carbidopa-Entacapone-Levodopa

0-1 month	1-3 months	3-6 months	6 months-1year	1-2 years	2 years or more
5	17	13	19	10	12

Adherence, Burden & Cost See details from patient evaluations ▼

Adherence

Taking treatment as prescribed

Always	61	79%
Usually	13	17%
Sometimes	3	4%
Never	0	0%

Burden

Difficulty being on treatment

Very	7	9%
Somewhat	5	6%
A little	20	26%
Not at all	45	58%

Cost

Paid out of pocket

$200+	5	6%
$100-199	3	4%
$50-99	10	13%
$25-49	12	16%
< $25	25	32%

See more information, including instructions, precautions, side effects, and interactions.

Patient Evaluations

See all 77 patient evaluations

keith1943

Sex: M

Mouth/throat: mild

Arms: mild

Chest: mild

Legs: mild

See profile
keith1943

6 x 37.5 mg-200 mg-150 mg daily

since Dec 30, 2009
Efficacy Moderate for Parkinson's Disease PD
Side Effects Moderate
Advice/Tips It's a real pain coordinating the Stalevo with consuming protein. I take one pill every 2 1/2 hours. When I take one, I have to wait at least one-half hour... See full evaluation

rose5

Sex: F

Mouth/throat: mild

Arms: moderate

Chest: mild

Legs: mild

See profile
rose5

4 x 25 mg-200 mg-100 mg daily

since Dec 13, 2009
Efficacy Major for Parkinson's Disease PD
Side Effects None
Advice/Tips Since the addition of Azilect 1mg, I have been able to lower my Stalevo dosing again. I now take Stalevo 100mg every 4 hours instead of every 3 1/2. Stalevo ... See full evaluation

mbsxxx

Sex: M

Mouth/throat: mild

Arms: mild

Chest: mild

Legs: mild

See profile
mbsxxx

6 x 12.5 mg-200 mg-50 mg daily

since Sep 16, 2008
Efficacy Moderate for Parkinson's Disease PD
Side Effects Mild
See full evaluation

See all 77 patient evaluations

Report created on March 20, 2010.

PatientsLikeMe ™

Carbidopa-Entacapone-Levodopa Treatment Report

What is Carbidopa-Entacapone-Levodopa?

Reasons taken & Efficacy

Side Effects

Dosages

Stop Reasons

Duration See details about how long patients take this treatment ▼ Duration Hide details ▲

Adherence, Burden & Cost See details from patient evaluations ▼

Patient Evaluations

See all 77 patient evaluations

Forum

100 mg all the time (24/7)	100mg as needed	25 mg-200 mg-100 mg all the time (24/7)	25 mg-200 mg-100 mg daily	daily	0.05 mg daily	3 mg daily	3 other daily	4 mg daily	4 other daily	5 intl units daily	6 mg daily	6 other daily	25 mg daily	12.5 mg-200 mg-50 mg daily	50 mg daily	18.75 mg-200 mg-75 mg daily	75 mg daily	80 mg daily	100 mg daily	25 mg-200 mg-100 mg daily	2 x 12.5 mg-200 mg-50 mg daily	125 mg daily	31.25 mg-200 mg-125 mg daily	150 mg daily	150 other daily	37.5 mg-200 mg-150 mg daily	3 x 12.5 mg-200 mg-50 mg daily	200 mg daily	200 other daily	2 x 25 mg-200 mg-100 mg daily	4 x 12.5 mg-200 mg-50 mg daily	3 x 18.75 mg-200 mg-75 mg daily	250 mg daily	2 x 31.25 mg-200 mg-125 mg daily	5 x 12.5 mg-200 mg-50 mg daily	2 x 37.5 mg-200 mg-150 mg daily	300 mg daily	3 x 25 mg-200 mg-100 mg daily	6 x 12.5 mg-200 mg-50 mg daily	350 mg daily	7 x 12.5 mg-200 mg-50 mg daily	3 x 31.25 mg-200 mg-125 mg daily	400 mg daily	4 x 25 mg-200 mg-100 mg daily	8 x 12.5 mg-200 mg-50 mg daily	3 x 37.5 mg-200 mg-150 mg daily	450 mg daily	4 x 31.25 mg-200 mg-125 mg daily	500 mg daily	5 x 25 mg-200 mg-100 mg daily	3 x 50 mg-200 mg-200 mg daily	4 x 37.5 mg-200 mg-150 mg daily	600 mg daily	6 x 25 mg-200 mg-100 mg daily	625 mg daily	650 mg daily	700 mg daily	7 x 25 mg-200 mg-100 mg daily	5 x 37.5 mg-200 mg-150 mg daily	750 mg daily	800 mg daily	8 x 25 mg-200 mg-100 mg daily	6 x 37.5 mg-200 mg-150 mg daily	900 mg daily	5 x 50 mg-200 mg-200 mg daily	1200 mg daily	6 x 50 mg-200 mg-200 mg daily
1	1	1	1	12	1	2	2	6	1	1	1	1	1	1	4	1	3	1	13	13	5	1	1	8	1	6	9	12	2	4	14	1	1	1	5	1	22	29	3	1	1	1	14	30	1	12	6	4	4	13	2	14	12	5	1	1	2	1	10	3	3	2	5	3	1	1	1

100 mg all the time (24/7)	100mg as needed	25 mg-200 mg-100 mg all the time (24/7)	25 mg-200 mg-100 mg daily	daily	0.05 mg daily	3 mg daily	3 other daily	4 mg daily	4 other daily	5 intl units daily	6 mg daily	6 other daily	25 mg daily	12.5 mg-200 mg-50 mg daily	50 mg daily	18.75 mg-200 mg-75 mg daily	75 mg daily	80 mg daily	100 mg daily	25 mg-200 mg-100 mg daily	2 x 12.5 mg-200 mg-50 mg daily	125 mg daily	31.25 mg-200 mg-125 mg daily	150 mg daily	150 other daily	37.5 mg-200 mg-150 mg daily	3 x 12.5 mg-200 mg-50 mg daily	200 mg daily	200 other daily	2 x 25 mg-200 mg-100 mg daily	4 x 12.5 mg-200 mg-50 mg daily	3 x 18.75 mg-200 mg-75 mg daily	250 mg daily	2 x 31.25 mg-200 mg-125 mg daily	5 x 12.5 mg-200 mg-50 mg daily	2 x 37.5 mg-200 mg-150 mg daily	300 mg daily	3 x 25 mg-200 mg-100 mg daily	6 x 12.5 mg-200 mg-50 mg daily	350 mg daily	7 x 12.5 mg-200 mg-50 mg daily	3 x 31.25 mg-200 mg-125 mg daily	400 mg daily	4 x 25 mg-200 mg-100 mg daily	8 x 12.5 mg-200 mg-50 mg daily	3 x 37.5 mg-200 mg-150 mg daily	450 mg daily	4 x 31.25 mg-200 mg-125 mg daily	500 mg daily	5 x 25 mg-200 mg-100 mg daily	3 x 50 mg-200 mg-200 mg daily	4 x 37.5 mg-200 mg-150 mg daily	600 mg daily	6 x 25 mg-200 mg-100 mg daily	625 mg daily	650 mg daily	700 mg daily	7 x 25 mg-200 mg-100 mg daily	5 x 37.5 mg-200 mg-150 mg daily	750 mg daily	800 mg daily	8 x 25 mg-200 mg-100 mg daily	6 x 37.5 mg-200 mg-150 mg daily	900 mg daily	5 x 50 mg-200 mg-200 mg daily	1200 mg daily	6 x 50 mg-200 mg-200 mg daily
1	1	1	1	12	1	2	2	6	1	1	1	1	1	1	4	1	3	1	13	13	5	1	1	8	1	6	9	12	2	4	14	1	1	1	5	1	22	29	3	1	1	1	14	30	1	12	6	4	4	13	2	14	12	5	1	1	2	1	10	3	3	2	5	3	1	1	1

PatientsLikeMe ™

Carbidopa-Entacapone-Levodopa Treatment Report

What is Carbidopa-Entacapone-Levodopa?

Reasons taken & Efficacy

Side Effects

Dosages

Stop Reasons

Duration See details about how long patients take this treatment ▼ Duration Hide details ▲

Adherence, Burden & Cost See details from patient evaluations ▼ Adherence, Burden & Cost Hide details ▲

Patient Evaluations

See all 77 patient evaluations

Forum

Adherence, Burden & Cost See details from patient evaluations ▼

100 mg all the time (24/7)	100mg as needed	25 mg-200 mg-100 mg all the time (24/7)	25 mg-200 mg-100 mg daily	daily	0.05 mg daily	3 mg daily	3 other daily	4 mg daily	4 other daily	5 intl units daily	6 mg daily	6 other daily	25 mg daily	12.5 mg-200 mg-50 mg daily	50 mg daily	18.75 mg-200 mg-75 mg daily	75 mg daily	80 mg daily	100 mg daily	25 mg-200 mg-100 mg daily	2 x 12.5 mg-200 mg-50 mg daily	125 mg daily	31.25 mg-200 mg-125 mg daily	150 mg daily	150 other daily	37.5 mg-200 mg-150 mg daily	3 x 12.5 mg-200 mg-50 mg daily	200 mg daily	200 other daily	2 x 25 mg-200 mg-100 mg daily	4 x 12.5 mg-200 mg-50 mg daily	3 x 18.75 mg-200 mg-75 mg daily	250 mg daily	2 x 31.25 mg-200 mg-125 mg daily	5 x 12.5 mg-200 mg-50 mg daily	2 x 37.5 mg-200 mg-150 mg daily	300 mg daily	3 x 25 mg-200 mg-100 mg daily	6 x 12.5 mg-200 mg-50 mg daily	350 mg daily	7 x 12.5 mg-200 mg-50 mg daily	3 x 31.25 mg-200 mg-125 mg daily	400 mg daily	4 x 25 mg-200 mg-100 mg daily	8 x 12.5 mg-200 mg-50 mg daily	3 x 37.5 mg-200 mg-150 mg daily	450 mg daily	4 x 31.25 mg-200 mg-125 mg daily	500 mg daily	5 x 25 mg-200 mg-100 mg daily	3 x 50 mg-200 mg-200 mg daily	4 x 37.5 mg-200 mg-150 mg daily	600 mg daily	6 x 25 mg-200 mg-100 mg daily	625 mg daily	650 mg daily	700 mg daily	7 x 25 mg-200 mg-100 mg daily	5 x 37.5 mg-200 mg-150 mg daily	750 mg daily	800 mg daily	8 x 25 mg-200 mg-100 mg daily	6 x 37.5 mg-200 mg-150 mg daily	900 mg daily	5 x 50 mg-200 mg-200 mg daily	1200 mg daily	6 x 50 mg-200 mg-200 mg daily
1	1	1	1	12	1	2	2	6	1	1	1	1	1	1	4	1	3	1	13	13	5	1	1	8	1	6	9	12	2	4	14	1	1	1	5	1	22	29	3	1	1	1	14	30	1	12	6	4	4	13	2	14	12	5	1	1	2	1	10	3	3	2	5	3	1	1	1