PatientsLikeMe ™

Back to Treatment Report

What is tolcapone?

Tolcapone prevents the breakdown of a chemical in your brain called dopamine (DO pa meen). It also helps other medicines work better in raising the levels of dopamine in your body. Low levels of dopamine are associated with Parkinson’s disease.

Tolcapone is used together with other medicines to treat symptoms of Parkinson’s disease, such as muscle stiffness, tremors, muscle spasms, and poor muscle control. Tolcapone is used only in combination with carbidopa and levodopa. It is not effective if it is used alone.

This medication is usually reserved for use only in people who have used carbidopa and levodopa without success in treating their Parkinson’s disease.

Tolcapone may also be used for purposes other than those listed in the medication guide.

Precautions

Instructions

Side-effects

Interactions

Precautions

Do not use tolcapone if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take tolcapone before the MAO inhibitor has cleared from your body.

Serious or fatal side effects on the liver have occurred in some people taking this medication. You may be required to read and sign a Patient Consent form before you get a prescription for tolcapone.

Do not take this medication if you are allergic to tolcapone, or if you have:

• liver disease; or
• if you have ever had muscle damage or fever and confusion caused by a medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether tolcapone passes into breast milk or if it could harm a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby.

Tolcapone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Dizziness may be more likely to occur when you rise from a sitting or lying position. Get up slowly to keep from falling.

Avoid drinking alcohol, which can increase some of the side effects of tolcapone.

Avoid using drugs that make you sleepy (such as cold medicine, pain medication, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). These medicines may increase drowsiness and dizziness caused by tolcapone.

Back to top

Instructions

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a tolcapone overdose may include nausea, vomiting, and dizziness.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Back to top

Side-effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• feeling light-headed, fainting;
• breathing problems;
• fever with muscle stiffness;
• fever with confusion; or
• severe and ongoing diarrhea.

Less serious side effects may be more likely to occur, such as:

• mild or occasional diarrhea (may occur long after you start taking tolcapone);
• hallucinations (seeing or hearing things);
• twitching or uncontrolled muscle movement;
• stiffness in your neck;
• nausea, vomiting, loss of appetite, constipation;
• dreaming more than usual;
• muscle cramps;
• headache;
• dry mouth, increased sweating; or
• discolored urine.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Back to top

Interactions

Before taking tolcapone, tell your doctor if you are using any of the following drugs:

• a blood thinner such as warfarin (Coumadin);
• methyldopa (Aldoclor, Aldomet, Aldoril);
• dobutamine (Dobutrex);
• desipramine (Norpramin);
• isoproterenol (Isuprel Mistometer); or
• apomorphine (Apokyn).

If you are using any of these drugs, you may not be able to use tolcapone, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect tolcapone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Back to top

Disclaimer