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Home > Community Treatment Reports and Side Effects > Carbidopa-Entacapone-Levodopa Treatment Report
What is Carbidopa-Entacapone-Levodopa?

The combination of levodopa, carbidopa, and entacapone is used for Parkinson's Disease. Levodopa is the precursor to dopamine, carbidopa slows the breakdown of levodopa, while entacapone improves the efficacy of levodopa.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose # of patients
# of patients with evaluations Efficacy
Major
Moderate
Slight
None
Can’t tell
Parkinson's Disease 420 112 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Stiffness/Spasticity 12 2 Efficacy_major Efficacy_slight
Other 11 3 Efficacy_major Efficacy_cant_tell
Increase effect of another treatment 9 2 Efficacy_major Efficacy_moderate
Improve mobility 6 1 Efficacy_major
Tremor in hands 4 0

See all 449 patients currently taking Carbidopa-Entacapone-Levodopa

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Reported Side Effects

Side effects as an overall problem

Severe
 19
Moderate
 25
Mild
 33
None
 43

Commonly reported side effects, conditions, and hospitalizations associated with Carbidopa-Entacapone-Levodopa

Dyskinesia 20
Nausea 10
Wearing off leg cramps 9
Wearing off increased tremors 8
Weight gain 5
Fatigue 5
See all 56 reported side effects ▼ See top 6 reported side effects ▲

Reported Dosages

Frequently reported dosages based on patients currently taking Carbidopa-Entacapone-Levodopa. See all 94 dosages ►

  25 mg-200 mg-100 mg daily 3 x 12.5 mg-200 mg-50 mg daily 4 x 12.5 mg-200 mg-50 mg daily 3 x 25 mg-200 mg-100 mg daily 300 mg daily 4 x 25 mg-200 mg-100 mg daily 3 x 37.5 mg-200 mg-150 mg daily 5 x 25 mg-200 mg-100 mg daily 600 mg daily 4 x 37.5 mg-200 mg-150 mg daily
  30 Number of Patients: 30 13 Number of Patients: 13 13 Number of Patients: 13 37 Number of Patients: 37 21 Number of Patients: 21 38 Number of Patients: 38 14 Number of Patients: 14 15 Number of Patients: 15 15 Number of Patients: 15 19 Number of Patients: 19  

Reported Stop Reasons

Why Patients Stopped Taking Carbidopa-Entacapone-Levodopa (multiple reasons could be selected)
Reason # Patients Percentage of patients
Side effects too severe 46   Side effects too severe: 34%
Doctor's advice 39   Doctor's advice: 29%
Did not seem to work 25   Did not seem to work: 19%
Other 18   Other: 13%
Expense 16   Expense: 12%
Not indicated 6   Not indicated: 4%
Personal research 5   Personal research: 4%
Course of treatment ended 1   Course of treatment ended: 1%

See all 125 patients who’ve stopped taking Carbidopa-Entacapone-Levodopa

Reported Duration See details about how long patients take this treatment ▼

Currently Taking Carbidopa-Entacapone-Levodopa

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Stopped Taking Carbidopa-Entacapone-Levodopa

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations ▼

Adherence

Taking treatment as prescribed

Adherence of Carbidopa-Entacapone-Levodopa

Always
 90 75%
Usually
 20 17%
Sometimes
 6 5%
Never
 4 3%

Burden

Difficulty being on treatment

Burden of Carbidopa-Entacapone-Levodopa

Very
 9 8%
Somewhat
 13 11%
A little
 26 22%
Not at all
 72 60%

Cost

Paid out of pocket

Cost of Carbidopa-Entacapone-Levodopa

$200+
 7 8%
$100-199
 7 8%
$50-99
 16 19%
$25-49
 22 26%
< $25
 30 36%

See more information, including instructions, precautions, side effects, and interactions.

Report created on February 12, 2012.