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What is Methotrexate?

Methotrexate is an antineoplastic drug used in the treatment of cancer. Also used as an antirheumatic for rheumatoid arthritis. Off label use in treatment of Crohn's disease and ectopic pregnancy. Experimental use in MS. It is given by mouth, by injection, via IV or intrathecally.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose # of patients
# of patients with evaluations Efficacy
Major
Moderate
Slight
None
Can’t tell
RA (Rheumatoid Arthritis) 620 151 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Psoriatic Arthritis 83 19 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_cant_tell
Psoriasis 77 19 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_cant_tell
MS (Multiple Sclerosis) 70 16 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Rheumatoid Arthritis 44 13 Efficacy_moderate Efficacy_slight Efficacy_none
Systemic Lupus Erythematosus 37 2 Efficacy_slight Efficacy_cant_tell

See all 789 patients currently taking Methotrexate

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Reported Side Effects

Side effects as an overall problem

Severe
 67
Moderate
 71
Mild
 71
None
 40

Commonly reported side effects, conditions, and hospitalizations associated with Methotrexate

Nausea 51
Fatigue 45
Hair loss 35
Nausea and vomiting 18
Stomach upset 17
Headaches 14
See all 136 reported side effects ▼ See top 6 reported side effects ▲

Reported Dosages

Frequently reported dosages based on patients currently taking Methotrexate. See all 85 dosages ►

  7.5 mg weekly 10 mg weekly 12.5 mg weekly 15 mg weekly 17.5 mg weekly 20 mg weekly 22.5 mg weekly 25 mg weekly 30 mg weekly 50 mg weekly
  60 Number of Patients: 60 85 Number of Patients: 85 47 Number of Patients: 47 138 Number of Patients: 138 34 Number of Patients: 34 155 Number of Patients: 155 12 Number of Patients: 12 133 Number of Patients: 133 11 Number of Patients: 11 10 Number of Patients: 10  

Reported Stop Reasons

Why Patients Stopped Taking Methotrexate (multiple reasons could be selected)
Reason # Patients Percentage of patients
Side effects too severe 183   Side effects too severe: 58%
Did not seem to work 97   Did not seem to work: 31%
Doctor's advice 82   Doctor's advice: 26%
Other 43   Other: 14%
Course of treatment ended 20   Course of treatment ended: 6%
Personal research 7   Personal research: 2%
Expense 6   Expense: 2%
Change in health plan coverage 6   Change in health plan coverage: 2%
Not indicated 5   Not indicated: 2%

See all 300 patients who’ve stopped taking Methotrexate

Reported Duration See details about how long patients take this treatment ▼

Currently Taking Methotrexate

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Stopped Taking Methotrexate

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations ▼

Adherence

Taking treatment as prescribed

Adherence of Methotrexate

Always
 212 85%
Usually
 29 12%
Sometimes
 2 1%
Never
 6 2%

Burden

Difficulty being on treatment

Burden of Methotrexate

Very
 20 8%
Somewhat
 46 18%
A little
 45 18%
Not at all
 138 55%

Cost

Paid out of pocket

Cost of Methotrexate

$200+
 0 0%
$100-199
 2 1%
$50-99
 5 3%
$25-49
 15 10%
< $25
 124 84%

See more information, including instructions, precautions, side effects, and interactions.

Report created on May 27, 2012.