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What is Modafinil?

Modafinil is stimulant used to improve wakefulness in patients narcolepsy and shift work sleep disorder; adjunctive therapy for obstructive sleep apnea. Off label it is used for attention-deficit/hyperactivity disorder and to treat fatigue in MS and other disorders.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose # of patients
# of patients with evaluations Efficacy
Major
Moderate
Slight
None
Can’t tell
Fatigue 1315 358 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
MS (Multiple Sclerosis) 547 46 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Excessive daytime sleepiness (somnolence) 328 115 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Brain fog 79 26 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Other 51 11 Efficacy_major Efficacy_moderate Efficacy_slight
Cognitive impairment 33 9 Efficacy_major Efficacy_moderate Efficacy_slight

See all 1616 patients currently taking Modafinil

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Reported Side Effects

Side effects as an overall problem

Severe
 33
Moderate
 74
Mild
 127
None
 269

Commonly reported side effects, conditions, and hospitalizations associated with Modafinil

Jittery feeling 49
Dry mouth (xerostomia) 46
Headaches 35
Sleep problems 30
Anxious mood 30
Heart rate increased 26
See all 93 reported side effects ▼ See top 6 reported side effects ▲

Reported Dosages

Frequently reported dosages based on patients currently taking Modafinil. See all 51 dosages ►

  200mg as needed 2 100mg as needed 100mg as needed daily 50 mg daily 100 mg daily 200 mg daily 300 mg daily 400 mg daily 600 mg daily
  60 Number of Patients: 60 11 Number of Patients: 11 85 Number of Patients: 85 21 Number of Patients: 21 19 Number of Patients: 19 368 Number of Patients: 368 689 Number of Patients: 689 36 Number of Patients: 36 267 Number of Patients: 267 9 Number of Patients: 9  

Reported Stop Reasons

Why Patients Stopped Taking Modafinil (multiple reasons could be selected)
Reason # Patients Percentage of patients
Did not seem to work 188   Did not seem to work: 30%
Other 141   Other: 23%
Expense 136   Expense: 22%
Side effects too severe 130   Side effects too severe: 21%
Doctor's advice 77   Doctor's advice: 12%
Change in health plan coverage 64   Change in health plan coverage: 10%
Personal research 26   Personal research: 4%
Course of treatment ended 13   Course of treatment ended: 2%
Not indicated 6   Not indicated: 1%

See all 604 patients who’ve stopped taking Modafinil

Reported Duration See details about how long patients take this treatment ▼

Currently Taking Modafinil

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Stopped Taking Modafinil

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations ▼

Adherence

Taking treatment as prescribed

Adherence of Modafinil

Always
 324 64%
Usually
 117 23%
Sometimes
 46 9%
Never
 16 3%

Burden

Difficulty being on treatment

Burden of Modafinil

Very
 21 4%
Somewhat
 40 8%
A little
 68 14%
Not at all
 374 74%

Cost

Paid out of pocket

Cost of Modafinil

$200+
 33 9%
$100-199
 21 6%
$50-99
 79 21%
$25-49
 100 27%
< $25
 134 36%

See more information, including instructions, precautions, side effects, and interactions.

Report created on February 08, 2012.