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What is Amitriptyline-Perphenazine?

The combination of amitriptyline, a tricyclic antidepressant, and perphenazine, an antipsychotic agent is used in the treatment of patients with moderate to severe anxiety and depression. Off label it is used for depression with psychotic features.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose # of patients
# of patients with evaluations Efficacy
Major
Moderate
Slight
None
Can’t tell
Sleep problems 3 0
Emotional lability 1 1 Efficacy_moderate
Other 1 0
Prevent migraine 1 1 Efficacy_none
Fibromyalgia 1 0
CNS Lupus 1 1 Efficacy_cant_tell

See all 4 patients currently taking Amitriptyline-Perphenazine

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Reported Side Effects

Side effects as an overall problem

Severe
0
Moderate
1
Mild
1
None
1

Commonly reported side effects, conditions, and hospitalizations associated with Amitriptyline-Perphenazine

Weight gain 1
Irritable and grouchy 1
Tiredness increased 1

Reported Dosages

  10 mg-2 mg daily 2 x 25 mg-2 mg daily 3 x 25 mg-2 mg daily
  2 Number of Patients: 2 1 Number of Patients: 1 1 Number of Patients: 1  

Reported Stop Reasons

Why Patients Stopped Taking Amitriptyline-Perphenazine (multiple reasons could be selected)
Reason # Patients Percentage of patients
Side effects too severe 3   Side effects too severe: 60%
Other 2   Other: 40%

See all 5 patients who’ve stopped taking Amitriptyline-Perphenazine

Currently Taking Amitriptyline-Perphenazine

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
0
0
0
0
0

Stopped Taking Amitriptyline-Perphenazine

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
0
0

Reported Adherence, Burden & Cost See details from patient evaluations

Adherence

Taking treatment as prescribed

Adherence of Amitriptyline-Perphenazine

Always
3 100%
Usually
0 0%
Sometimes
0 0%
Never
0 0%

Burden

Difficulty being on treatment

Burden of Amitriptyline-Perphenazine

Very
0 0%
Somewhat
0 0%
A little
0 0%
Not at all
3 100%

Cost

Paid out of pocket

Cost of Amitriptyline-Perphenazine

$200+
0 0%
$100-199
0 0%
$50-99
0 0%
$25-49
0 0%
< $25
1 100%

See more information, including instructions, precautions, side effects, and interactions.

Report created on February 12, 2012.