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Home > Community Treatment Reports and Side Effects > Amitriptyline Treatment Report
What is Amitriptyline?

Amitriptyline is a tricyclic antidepressant approved for the treatment of depression. Off label amitripyline is used for certain chronic and neuropathic (nerve) pain and for prevention of migraine headaches.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose # of patients
# of patients with evaluations Efficacy
Major
Moderate
Slight
None
Can’t tell
Insomnia 322 103 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Fibromyalgia 288 92 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Pain 269 81 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Depressed mood 148 54 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Sleep problems 140 47 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Nerve pain (neuralgia) 113 48 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell

See all 1428 patients currently taking Amitriptyline

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Reported Side Effects

Side effects as an overall problem

Severe
 69
Moderate
 123
Mild
 143
None
 162

Commonly reported side effects, conditions, and hospitalizations associated with Amitriptyline

Dry mouth (xerostomia) 71
Weight gain 62
Grogginess 36
Excessive daytime sleepiness (somnolence) 29
Hangover effect 27
Drowsiness 17
See all 127 reported side effects ▼ See top 6 reported side effects ▲

Reported Dosages

Frequently reported dosages based on patients currently taking Amitriptyline. See all 59 dosages ►

  10 mg daily 20 mg daily 25 mg daily 30 mg daily 40 mg daily 50 mg daily 75 mg daily 100 mg daily 150 mg daily 200 mg daily
  293 Number of Patients: 293 117 Number of Patients: 117 316 Number of Patients: 316 52 Number of Patients: 52 19 Number of Patients: 19 332 Number of Patients: 332 94 Number of Patients: 94 128 Number of Patients: 128 35 Number of Patients: 35 17 Number of Patients: 17  

Reported Stop Reasons

Why Patients Stopped Taking Amitriptyline (multiple reasons could be selected)
Reason # Patients Percentage of patients
Did not seem to work 209   Did not seem to work: 39%
Side effects too severe 196   Side effects too severe: 37%
Doctor's advice 117   Doctor's advice: 22%
Other 89   Other: 17%
Course of treatment ended 22   Course of treatment ended: 4%
Personal research 21   Personal research: 4%
Not indicated 12   Not indicated: 2%
Expense 9   Expense: 2%
Change in health plan coverage 1   Change in health plan coverage: 0%

See all 511 patients who’ve stopped taking Amitriptyline

Reported Duration See details about how long patients take this treatment ▼

Currently Taking Amitriptyline

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Stopped Taking Amitriptyline

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations ▼

Adherence

Taking treatment as prescribed

Adherence of Amitriptyline

Always
 394 79%
Usually
 76 15%
Sometimes
 20 4%
Never
 7 1%

Burden

Difficulty being on treatment

Burden of Amitriptyline

Very
 30 6%
Somewhat
 34 7%
A little
 67 13%
Not at all
 366 74%

Cost

Paid out of pocket

Cost of Amitriptyline

$200+
 1 0%
$100-199
 2 1%
$50-99
 2 1%
$25-49
 7 2%
< $25
 308 96%

See more information, including instructions, precautions, side effects, and interactions.

Report created on February 10, 2012.