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Brand Names: Fampridine, Fampridine-SR

What is 4-Aminopyridine (4-AP)? 4-Aminopyridine blocks potassium channels and prolongs action potentials thereby increasing transmitter release at the neuromuscular junction and elsewhere. It has been under study for spinal cord injuries and for Multiple Sclerosis.


Reasons Taken

91 patients in the community are taking or have taken 4-Aminopyridine (4-AP).

Reason # Patients Percentage of patients
Other 24 26%
Mobility 18 19%
Fatigue 12 13%
Stiffness/spasticity 7 7%
Slow my MS progress 5 5%
General health 3 3%
disease-related symptoms 2 2%
Uhthoff's phenomenon 1 1%
Brain fog 1 1%
Numbness in my hands, arms, legs, and waist 1 1%
Neuropathy pain 1 1%
I walk slower tire more easily 1 1%
Sensation 1 1%
Weakness in legs 1 1%
Support another treatment 1 1%

Dosages

Based on the patients currently taking 4-Aminopyridine (4-AP).

Top 10 (Show all)

All (Show Top 10)

  0 mg Daily 0 other Daily 10 mg As needed 2 Daily 3.5 mg Daily 5 mg Daily 6 mg Daily 7.5 mg Daily 10 g Daily 10 mcg Daily 10 mg Daily 15 mg Daily 20 mg Daily 25 mg Daily 30 mg Daily 37.5 mg Daily 40 mg Daily 40 tbs. Daily 60 mg Daily
  1 Number of Patients: 1 1 Number of Patients: 1 1 Number of Patients: 1 1 Number of Patients: 1 1 Number of Patients: 1 1 Number of Patients: 1 1 Number of Patients: 1 1 Number of Patients: 1 1 Number of Patients: 1 1 Number of Patients: 1 7 Number of Patients: 7 4 Number of Patients: 4 27 Number of Patients: 27 1 Number of Patients: 1 15 Number of Patients: 15 1 Number of Patients: 1 6 Number of Patients: 6 1 Number of Patients: 1 2 Number of Patients: 2  

Duration

How long current patients have been taking 4-Aminopyridine (4-AP) or how long patients were taking 4-Aminopyridine (4-AP) before stopping.

Currently taking 4-Aminopyridine (4-AP)

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
6
7
21
8
10
9

Stopped taking 4-Aminopyridine (4-AP)

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
3
4
3
2
1
2
Why Patients Stopped Taking 4-Aminopyridine (4-AP) (multiple reasons could be selected)
Reason # Patients Percentage of patients
Did not seem to work 6 40% Did not seem to work: 40%
Other 4 27% Other: 27%
Doctor's advice 3 20% Doctor's advice: 20%
Side effects too severe 2 13% Side effects too severe: 13%
Course of treatment ended 1 7% Course of treatment ended: 7%

Patient Reported Evaluations

Results from 13 patient evaluations. See the overall results and all individual evaluations.

Efficacy (Effect based on reason taken)

Major 50% 3
Moderate 50% 3

Other

Side-effects (as an overall problem)

Severe 8% 1
Moderate 8% 1
Mild 8% 1
None 77% 10

Top reported side-effects include: Dizziness/feeling like passing out, Anxiety, Nausea

Summary results are based on 13 individual responses. For more information, see overall results for Adherence, Burden and Cost.

Individual Patient Reported Evaluations (2 of 13)

  • Lillian
    Sex: F
    Sensation: None
    Overall: None
    Cognition: mild
    Vision: none
    Speech: none
    Swallowing: mild
    Upper limb: mild
    Walking: moderate
    See profile
  • Lillian
  • by Lillian
    Aug 20, 2006
  • EfficacyMajor
  • Side-effectsNone
  • Other
Advice/Tips
How much it will improve the quality of their life.

  • Thekla
    Sex: F
    Sensation: Moderate
    Overall: Mild
    Cognition: mild
    Vision: none
    Speech: none
    Swallowing: none
    Upper limb: moderate
    Walking: moderate
    See profile
  • Thekla
  • by Thekla
    Aug 21, 2008
  • EfficacyModerate
  • Side-effectsNone
  • Other
Advice/Tips
it has greatly improved my energy and bladder function -- mobility has changed very little. We need to be able to rate efficacy of each "purpose"

See all evaluation results for 4-Aminopyridine (4-AP)



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