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What is conjugated estrogens-medroxyPROGESTERone?

Conjugated estrogens are a mixture of estrogen hormones. Estrogen is a female sex hormone produced by the ovaries that is necessary for many processes in the body.

Medroxyprogesterone is also a female hormone, usually called "progesterone.” It is important for the regulation of ovulation and menstruation.

Together, conjugated estrogens and medroxyprogesterone are used to treat the symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation, and to prevent thinning of the bones (osteoporosis).

Conjugated estrogens and medroxyprogesterone should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

Conjugated estrogens and medroxyprogesterone may also be used for purposes other than those listed in this medication guide.

Precautions

Instructions

Side-effects

Interactions

Precautions

Do not use this medication if you have:

• a history of heart attack, stroke, or blood clot (especially in your lung or your lower body);
• abnormal vaginal bleeding that a doctor has not checked;
• liver disease; or
• any type of breast, uterine, or hormone-dependent cancer.

Before using conjugated estrogens and medroxyprogesterone, tell your doctor if you are allergic to any drugs, or if you have:

• high blood pressure, heart disease, or circulation problems;
• a personal or family history of stroke;
• endometriosis;
• liver or kidney disease;
• asthma;
• epilepsy or other seizure disorder;
• migraines;
• diabetes;
• underactive thyroid;
• high cholesterol or triglycerides;
• high or low levels of calcium in your blood;
• porphyria;
• systemic lupus erythematosus (SLE);
• gallbladder disease; or
• if you have had your uterus removed (hysterectomy).

If you have any of these conditions, you may not be able to use conjugated estrogens and medroxyprogesterone, or you may need a dosage adjustment or special tests during treatment.

Conjugated estrogens increase your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using conjugated estrogens may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using conjugated estrogens and medroxyprogesterone.

Long-term conjugated estrogens treatment may increase your risk of stroke or blood clots. Talk with your doctor about your individual risks before using conjugated estrogens long term, especially if you smoke or are overweight. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

FDA pregnancy category X. This medication can cause birth defects. Do not use conjugated estrogens and medroxyprogesterone if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.

Conjugated estrogens and medroxyprogesterone can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby.

Do not give this medication to anyone under 18 years old without the advice of a doctor.

Do not smoke while using this medication. Smoking can increase your risk of blood clots, stroke, or heart attack caused by conjugated estrogens and medroxyprogesterone.

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Instructions

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a conjugated estrogens and medroxyprogesterone overdose may include nausea, vomiting, or vaginal bleeding.

Take the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

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Side-effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking this medication and call your doctor at once if you have any of these serious side effects:

• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
• sudden numbness or weakness, especially on one side of the body;
• sudden headache, confusion, problems with vision, speech, or balance;
• pain or swelling in your lower leg;
• abnormal vaginal bleeding;
• migraine headache;
• pain, swelling, or tenderness in your stomach;
• confusion, problems with memory or concentration;
• jaundice (yellowing of the skin or eyes);
• swelling in your hands, ankles, or feet; or
• a breast lump.

Continue taking the medication and talk to your doctor if you have any of these less serious side effects:

• mild nausea, vomiting, bloating, stomach pain;
• breast pain, tenderness, or swelling;
• freckles or darkening of facial skin;
• acne, increased hair growth, loss of scalp hair;
• changes in weight or appetite;
• problems with contact lenses;
• vaginal itching or discharge;
• changes in your menstrual periods, decreased sex drive; or
• headache, nervousness, dizziness, tired feeling.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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Interactions

Before taking conjugated estrogens and medroxyprogesterone, tell your doctor if you are taking any of the following medicines:

• St. John's wort;
• carbamazepine (Carbatrol, Tegretol)
• phenobarbital (Luminal, Solfoton);
• rifampin (Rifadin, Rifater, Rifamate, Rimactane);
• ritonavir (Norvir);
• ketoconazole (Nizoral) or itraconazole (Sporanox); or
• an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., Ery-Tab, Erythrocin, E-Mycin), itraconazole (Sporanox) or ketoconazole (Nizoral).

If you are using any of these drugs, you may not be able to use conjugated estrogens and medroxyprogesterone, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect conjugated estrogens and medroxyprogesterone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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