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What is Entacapone?

Entacapone is an inhibitor of catechol-O-methyltransferase (COMT) and is indicated as an adjunct treatment for patients taking levodopa and carbidopa for Parkinson’s Disease who experience the signs and symptoms of end-of-dose “wearing-off”.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose # of patients
# of patients with evaluations Efficacy
Major
Moderate
Slight
None
Can’t tell
Parkinson's Disease 206 27 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Increase effect of another treatment 39 11 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Wearing off effect 16 5 Efficacy_major Efficacy_moderate
Other 6 3 Efficacy_major Efficacy_moderate
Stiffness/Spasticity 6 1 Efficacy_cant_tell
to extend effect of Sinimet 5 2 Efficacy_moderate Efficacy_cant_tell

See all 237 patients currently taking Entacapone

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Reported Dosages

Frequently reported dosages based on patients currently taking Entacapone. See all 19 dosages

  daily 200 mg daily 300 mg daily 400 mg daily 600 mg daily 800 mg daily 1,000 mg daily 1,200 mg daily 1,400 mg daily 1,600 mg daily
  5 Number of Patients: 5 31 Number of Patients: 31 5 Number of Patients: 5 19 Number of Patients: 19 52 Number of Patients: 52 66 Number of Patients: 66 30 Number of Patients: 30 11 Number of Patients: 11 5 Number of Patients: 5 3 Number of Patients: 3  

Reported Stop Reasons

Why Patients Stopped Taking Entacapone (multiple reasons could be selected)
Reason # Patients Percentage of patients
Did not seem to work 21   Did not seem to work: 30%
Side effects too severe 21   Side effects too severe: 30%
Doctor's advice 17   Doctor's advice: 25%
Other 12   Other: 17%
Expense 6   Expense: 9%
Not indicated 2   Not indicated: 3%
Course of treatment ended 2   Course of treatment ended: 3%
Personal research 1   Personal research: 1%

See all 63 patients who’ve stopped taking Entacapone

Currently Taking Entacapone

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0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
0

Stopped Taking Entacapone

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations

Adherence

Taking treatment as prescribed

Adherence of Entacapone

Always
37 76%
Usually
12 24%
Sometimes
0 0%
Never
0 0%

Burden

Difficulty being on treatment

Burden of Entacapone

Very
3 6%
Somewhat
8 16%
A little
7 14%
Not at all
31 63%

Cost

Paid out of pocket

Cost of Entacapone

$200+
4 11%
$100-199
3 9%
$50-99
1 3%
$25-49
12 34%
< $25
15 43%

See more information, including instructions, precautions, side effects, and interactions.

Report created on May 27, 2012.