I've been on a roller coaster ride since my dxs of MS. I have tried several biological therapies with very little success. I believe I went through my Relapsing-Remitting stage of my MS before my diagnosis after the dx. I went right into Secondary Progressive MS and have been on a steady decline in my health. My abilities to perform my daily activities has been on a steady decline every since my dx of MS. I'm at the point where I have lost my ability to walk, writing has become very difficult, fatigue is to the point where I can't hardly do much of anything for any length of time, cognitive abilities are getting harder to deal with as time passes.