For me year 1 was getting use to the fact I had MS and the shots. I passed out the first few times I gave myself a shot! Then I had to ice an area for 30 min, made a big production of it-now I can be walking down the hall, swab and shot without a thought. I will say this last year had been the worse- bladder/bowel issues were horrible, embarrassing, stressful. I had gained 20 lbs since diagnosis - and being only 5'3 there aren't a lot of places to put it. But with getting the right medications in place, counseling, pilates, and most of all support of friends, family things are so much better!