Over ten years and seven doctors later, I was diagnosed with Secondary Progressive MS on 5/4/09. Tysabri helps with the fatigue & memory. Depression, foot drop, speech and cognitive difficulties are still ever-present. Enough gloom and doom. On the positive side, thank heavens the horrible fatigue and memory problems are much better, and I can actually see the humor in unwittingly putting a full glass of water in the cabinet with the other glasses. Imagine my husband's wet surprise when he picked THAT glass to get out of the cabinet! The napkins in the freezer was pretty funny too. :)