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What is Natalizumab?

Natalizumab is a monoclonal antibody given by infusion and used in the treatment of MS and Crohn's disease. It has been shown to slow progression and reduce relapses in MS. It is currently sold under the brand name Tysabri.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose	# of patients	# of patients with evaluations Efficacy
MS (Multiple Sclerosis)	1399	497
Other	34	9
Improve mobility	26	12
General health	23	6
Fatigue	22	11
Stiffness/Spasticity	20	8

See all 44 reasons taken ▼

See all 1357 patients currently taking Natalizumab

Mouse over the table for more information

Reported Side Effects

Side effects as an overall problem

Severe	37
Moderate	60
Mild	155
None	280

Commonly reported side effects, conditions, and hospitalizations associated with Natalizumab

See all 183 reported side effects ▼ See top 6 reported side effects ▲
Headaches	60	60
Tiredness	53	53
Fear of PML	25	25
Fatigue	17	17
Stomach pain	14	14
Urinary Tract Infection UTI	14	14
Allergic reaction	13	13
Head pain	13	13
Nausea	13	13
Mood changes	11	11
Itchy rash	10	10
Back pain	6	6
Weakness in legs	6	6
Migraine headaches	6	6
Joint pain	5	5
Itching (pruritus)	4	4
Hair loss (alopecia)	4	4
Generalized weakness (asthenia)	4	4
Bladder problems	4	4
Lethargy	3	3
Muscle and joint pain	3	3
Infection	3	3
Flu like symptoms	3	3
Elevated liver enzymes	3	3
Increased fatigue	3	3
Pain in right eye	2	2
I was tired after in infusion but fine the next day	2	2
Body Aches	2	2
Brain fog	2	2
Metallic taste in mouth	2	2
Diarrhea	2	2
Hospitalization	2	2
Depressed mood	2	2
Breathing difficulty	2	2
Blurry vision	2	2
Anxious mood	2	2
Mental fatigue or exhaustion	2	2
JC virus present in blood test	2	2
Pain in legs	2	2
Weight gain	2	2
Insomnia	2	2
Hives (urticaria)	2	2
Chills/fever	2	2
Flushed	2	2
Dizziness	2	2
Rash or skin problems	2	2
Joint stiffness	1	1
Pain in hands	1	1
Sleepiness	1	1
Addiction	1	1
Joint pain in elbows and knees	1	1
Drowsiness	1	1
Dizziness and feeling faint	1	1
Chills	1	1
Nausea and vomiting	1	1
Bad taste in mouth	1	1
Loss of sex drive (libido)	1	1
Hypersensitivity reaction	1	1
Stomach upset	1	1
Abdominal cramps	1	1
Nausea if taken on empty stomach	1	1
Difficulty thinking	1	1
Increased energy	1	1
Wears off too soon	1	1
Raised body temperature	1	1
Unexplained itching	1	1
Cognitive impairment	1	1
Rashes (redness, swelling)	1	1
Tired and weak next day	1	1
face breaking out mildly	1	1
procressing of ms	1	1
Sinus congestion	1	1
Bruise easily	1	1
Numbness in legs	1	1
problems breathing (asthma issues at some level)	1	1
Weakness in left leg	1	1
Balance worsened	1	1
Near blackouts	1	1
Sinus infection	1	1
muscle deterioration	1	1
Hair whiting	1	1
Pustules	1	1
gums desolving	1	1
Easily get sick	1	1
Dizziness with nausea	1	1
Relapse MS (exacerbation)	1	1
Depression with suicidal thoughts	1	1
Pins and needles in feet	1	1
Sinus problems	1	1
Pressure headaches	1	1
chest/respiratory symtoms	1	1
Developed Antibodies	1	1
feel more disabled	1	1
Vision problem due to fatigue heat and stress	1	1
Clear vision	1	1
Better balance	1	1
Neuropathy in feet	1	1
Drugged feeling	1	1
Swollen joints	1	1
Several acute dizzy spells	1	1
Joint tenderness	1	1
Pins and needles in hands	1	1
Chest tightness	1	1
Throat infection	1	1
Increased MS relapses	1	1
a certain freshness	1	1
Cold chills	1	1
Memory and cognition problems	1	1
Painful lymph nodes (glands)	1	1
"Out of Sorts" for approx. 1 day	1	1
Rash on legs	1	1
Deep leg pain	1	1
Difficulty walking	1	1
Swollen tonsils	1	1
infusio sensitivity	1	1
Fatigue post infusion for day and a half	1	1
Upper respiratory infection	1	1
Recurring Urinary Tract Infection UTI	1	1
Acute bronchitis	1	1
lymphocytosis	1	1
Sherman	1	1
Mild & managable vaginitis sometimes for 5 or 6 days after infusion	1	1
Breast Cancer recurrence on Tysabri	1	1
Bullous pemphigoid	1	1
Headaches all day	1	1
Weakness in hip	1	1
Pain inside the bones	1	1
Pain in veins during infusion	1	1
Tired after dose through next day	1	1
Risk of PML	1	1
Very tired right after treatment	1	1
Chronic Fatigue Syndrome	1	1
Genital Herpes	1	1
Cellulitis	1	1
Mild Depression	1	1
Bronchitis	1	1
Eczema	1	1
Hospitalization	1	1
Pain	1	1
Emotional lability	1	1
Swollen feet	1	1
Generalized muscle aches	1	1
Heartburn	1	1
Low blood pressure	1	1
Cramps in calf muscles	1	1
Racing heart feeling	1	1
Mood swings	1	1
Excessive daytime sleepiness (somnolence)	1	1
Acid reflux	1	1
Bruising	1	1
Weight loss	1	1
Yeast Infection (candida)	1	1
Dry eyes	1	1
Paranoia	1	1
Cough	1	1
Difficulty sleeping through night	1	1
Dry mouth (xerostomia)	1	1
Lose train of thought	1	1
Sore throat (Pharyngitis)	1	1
Nose infection	1	1
Mouth/throat infection	1	1
Herpes outbreak	1	1
Shingles rash	1	1
Bladder infection	1	1
Problems concentrating	1	1
Cold sores (fever blisters)	1	1
Arthritis pain	1	1
Progressive Leukocytosis	1	1
Shooting pain in head	1	1
Euphoria	1	1
Fever	1	1
Myoclonus	1	1
Muscle weakness	1	1
Loss of short term memory	1	1
Sweating excessive	1	1
Cold hands and feet	1	1
Muscle fatigue	1	1
None	1	1
Pain in lower back	1	1
Confusion	1	1
Abdominal pain	1	1
Immune system weak	1	1
Jaundice	1	1

Reported Dosages

Frequently reported dosages based on patients currently taking Natalizumab. See all 28 dosages ►

monthly	300mg/15mL as needed	1 monthly	1 other monthly	30 mg monthly	200 mg monthly	300 mg monthly	300 mg/15 mL monthly	300 mg/15 mL every 4 weeks	300 mg/15 mL daily
137	7	4	3	3	4	40	489	634	13

Reported Stop Reasons

Why Patients Stopped Taking Natalizumab (multiple reasons could be selected)
Reason	# Patients	Percentage of patients
Doctor's advice	129
Side effects too severe	125
Other	117
Did not seem to work	93
Personal research	31
Expense	21
Course of treatment ended	11
Change in health plan coverage	9
Not indicated	4

See all 371 patients who’ve stopped taking Natalizumab

Reported Duration See details about how long patients take this treatment ▼ Reported Duration Hide details ▲

Currently Taking Natalizumab

A bar graph

0-1 month	1-3 months	3-6 months	6 months-1year	1-2 years	2 years or more
7	15	21	63	111	265

Stopped Taking Natalizumab

A bar graph

0-1 month	1-3 months	3-6 months	6 months-1year	1-2 years	2 years or more
27	44	53	70	86	75

Reported Adherence, Burden & Cost See details from patient evaluations ▼

Adherence

Taking treatment as prescribed

Adherence of Natalizumab

Always	493	93%
Usually	25	5%
Sometimes	2	0%
Never	12	2%

Burden

Difficulty being on treatment

Burden of Natalizumab

Very	27	5%
Somewhat	70	13%
A little	141	27%
Not at all	294	55%

Cost

Paid out of pocket

Cost of Natalizumab

$200+	89	24%
$100-199	25	7%
$50-99	33	9%
$25-49	34	9%
< $25	183	49%

See more information, including instructions, precautions, side effects, and interactions.

Patient Evaluations

See all 532 patient evaluations

vbeachy

Sex: M

Sensation: Moderate

Overall: None

Cognition: none

Vision: mild

Speech: none

Swallowing: none

Upper limb: none

Walking: mild
vbeachy

300 mg monthly

since Feb 05, 2012
Efficacy Major for MS (Multiple Sclerosis)
Side Effects Mild
See full evaluation

syl

Sex: F

Sensation: Moderate

Overall: Mild

Cognition: moderate

Vision: moderate

Speech: mild

Swallowing: mild

Upper limb: moderate

Walking: moderate
syl

300 mg/15 mL monthly

since Jan 05, 2012
Efficacy Major for MS (Multiple Sclerosis)
Side Effects Mild
Advice/Tips Tysabri was very beneficial to me and I responded well to it. After testing positive for the JC virus and having taken 46 infusions my dr was concerned. Sh... See full evaluation

msladyinca

Sex: F

Sensation: Moderate

Overall: Mild

Cognition: none

Vision: none

Speech: none

Swallowing: none

Upper limb: moderate

Walking: severe
msladyinca

300 mg/15 mL every 4 weeks

since Sep 28, 2010
Efficacy Major for To prevent further relapses and slow the disease process down
Side Effects None
Advice/Tips I'm still relapse free as of October 16th, 2006. My MS is still stable and my infusion next month will mark my treatment time being as more than four years,... See full evaluation

See all 532 patient evaluations

Report created on February 12, 2012.

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