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What is SAMe (S-adenosyl-L-methionine)?

S-adenosyl-L-methionine (SAMe) is an amino acid. As a supplement it's use is promoted for depression, osteoarthritis, and cholestasis of pregnancy and intrahepatic cholestasis associated with liver disease.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose # of patients
# of patients with evaluations Efficacy
Major
Moderate
Slight
None
Can’t tell
Depressed mood 24 11 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_cant_tell
Treat my mood condition(s) 18 10 Efficacy_moderate Efficacy_none Efficacy_cant_tell
Other 7 2 Efficacy_major Efficacy_moderate
Fibromyalgia 7 4 Efficacy_none Efficacy_cant_tell
General health 6 1 Efficacy_cant_tell
Joint health 4 1 Efficacy_slight

See all 45 patients currently taking SAMe (S-adenosyl-L-methionine)

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Reported Side Effects

Side effects as an overall problem

Severe
 3
Moderate
 4
Mild
 3
None
 21

Commonly reported side effects, conditions, and hospitalizations associated with SAMe (S-adenosyl-L-methionine)

Stomach pain 3
Headaches 2
Restless feeling in legs 1
Mania 1
Heart palpitations 1
Hyperreflexia 1
See all 13 reported side effects ▼ See top 6 reported side effects ▲

Reported Dosages

Frequently reported dosages based on patients currently taking SAMe (S-adenosyl-L-methionine). See all 14 dosages ►

  2 mg daily 4 mg daily 50 mg daily 200 mg daily 250 mg daily 300 mg daily 400 mg daily 600 mg daily 750 mg daily 800 mg daily
  1 Number of Patients: 1 1 Number of Patients: 1 2 Number of Patients: 2 7 Number of Patients: 7 1 Number of Patients: 1 1 Number of Patients: 1 21 Number of Patients: 21 2 Number of Patients: 2 1 Number of Patients: 1 6 Number of Patients: 6  

Reported Stop Reasons

Why Patients Stopped Taking SAMe (S-adenosyl-L-methionine) (multiple reasons could be selected)
Reason # Patients Percentage of patients
Expense 15   Expense: 41%
Did not seem to work 13   Did not seem to work: 35%
Other 8   Other: 22%
Side effects too severe 6   Side effects too severe: 16%
Doctor's advice 2   Doctor's advice: 5%
Personal research 2   Personal research: 5%
Not indicated 2   Not indicated: 5%

See all 37 patients who’ve stopped taking SAMe (S-adenosyl-L-methionine)

Reported Duration See details about how long patients take this treatment ▼

Currently Taking SAMe (S-adenosyl-L-methionine)

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
0
0

Stopped Taking SAMe (S-adenosyl-L-methionine)

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations ▼

Adherence

Taking treatment as prescribed

Adherence of SAMe (S-adenosyl-L-methionine)

Always
 21 68%
Usually
 9 29%
Sometimes
 1 3%
Never
 0 0%

Burden

Difficulty being on treatment

Burden of SAMe (S-adenosyl-L-methionine)

Very
 2 6%
Somewhat
 4 13%
A little
 6 19%
Not at all
 19 61%

Cost

Paid out of pocket

Cost of SAMe (S-adenosyl-L-methionine)

$200+
 0 0%
$100-199
 0 0%
$50-99
 4 20%
$25-49
 9 45%
< $25
 7 35%

See more information, including instructions, precautions, side effects, and interactions.

Report created on February 10, 2012.