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What is Bupropion?

Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder (SAD) and as an adjunct in smoking cessation. Off label used for Attention-deficit/hyperactivity and bipolar disorders.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose # of patients
# of patients with evaluations Efficacy
Major
Moderate
Slight
None
Can’t tell
Depressed mood 1088 341 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Major Depressive Disorder 548 137 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Treat my mood condition(s) 348 104 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Dysthymia 127 33 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Anxious mood 93 26 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_cant_tell
Other 85 21 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell

See all 2084 patients currently taking Bupropion

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Reported Side Effects

Side effects as an overall problem

Severe
103
Moderate
123
Mild
205
None
291

Commonly reported side effects, conditions, and hospitalizations associated with Bupropion

Dry mouth (xerostomia) 73
Insomnia 41
Headaches 30
Shakiness 28
Agitation 25
Constipation 23
See all 235 reported side effects See top 6 reported side effects

Reported Dosages

Frequently reported dosages based on patients currently taking Bupropion. See all 65 dosages

  75 mg daily 100 mg daily 150 mg daily 150 mg/24 hours daily 200 mg daily 2 x 150 mg/24 hours daily 300 mg/24 hours daily 300 mg daily 400 mg daily 450 mg daily
  84 Number of Patients: 84 142 Number of Patients: 142 315 Number of Patients: 315 234 Number of Patients: 234 152 Number of Patients: 152 67 Number of Patients: 67 452 Number of Patients: 452 397 Number of Patients: 397 74 Number of Patients: 74 103 Number of Patients: 103  

Reported Stop Reasons

Why Patients Stopped Taking Bupropion (multiple reasons could be selected)
Reason # Patients Percentage of patients
Did not seem to work 247   Did not seem to work: 34%
Side effects too severe 235   Side effects too severe: 33%
Doctor's advice 186   Doctor's advice: 26%
Other 146   Other: 20%
Expense 60   Expense: 8%
Course of treatment ended 42   Course of treatment ended: 6%
Personal research 34   Personal research: 5%
Change in health plan coverage 20   Change in health plan coverage: 3%
Not indicated 11   Not indicated: 2%

See all 679 patients who’ve stopped taking Bupropion

Currently Taking Bupropion

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0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Stopped Taking Bupropion

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0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations

Adherence

Taking treatment as prescribed

Adherence of Bupropion

Always
569 79%
Usually
120 17%
Sometimes
18 2%
Never
15 2%

Burden

Difficulty being on treatment

Burden of Bupropion

Very
36 5%
Somewhat
40 6%
A little
121 17%
Not at all
525 73%

Cost

Paid out of pocket

Cost of Bupropion

$200+
7 1%
$100-199
11 2%
$50-99
42 9%
$25-49
72 15%
< $25
347 72%

See more information, including instructions, precautions, side effects, and interactions.

Report created on February 12, 2012.