What is Duloxetine?
Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It is used for depression, general anxiety disorder, pain associated with diabetic neuropathy and for fibromyalgia.
Reported Side Effects
Side effects
as an overall problem
Commonly reported side effects, conditions, and hospitalizations associated with Duloxetine
|
Nausea
|
128 |
|
|
Sex drive (libido) decreased
|
116 |
|
|
Sweating increased
|
96 |
|
|
Dizziness
|
95 |
|
|
Weight gain
|
80 |
|
|
Insomnia
|
74 |
|
|
Brain cloud
|
72 |
|
|
Feel flat
|
58 |
|
|
Dry mouth (xerostomia)
|
57 |
|
|
Constipation
|
43 |
|
|
Sedation
|
41 |
|
|
Sweating excessive
|
30 |
|
|
Difficulty with orgasm
|
26 |
|
|
Fatigue
|
20 |
|
|
Mania
|
19 |
|
|
Drowsiness
|
15 |
|
|
Headaches
|
15 |
|
|
Sexual dysfunction
|
15 |
|
|
Hospitalization
|
14 |
|
|
Excessive daytime sleepiness (somnolence)
|
13 |
|
|
Loss of appetite
|
12 |
|
|
Brain zaps
|
12 |
|
|
Night sweats
|
11 |
|
|
Migraine headaches
|
11 |
|
|
Anxious mood
|
10 |
|
|
Nausea and vomiting
|
10 |
|
|
Hot flashes
|
9 |
|
|
Tiredness
|
9 |
|
|
Loss of sex drive (libido)
|
8 |
|
|
Dry throat
|
8 |
|
|
Mood swings
|
8 |
|
|
Brain fog
|
8 |
|
|
Blurry vision
|
8 |
|
|
Difficulty sleeping through night
|
8 |
|
|
Depressed mood
|
8 |
|
|
Restless feeling in legs
|
7 |
|
|
Decreased appetite
|
7 |
|
|
Elevated blood pressure
|
7 |
|
|
Depression with suicidal thoughts
|
7 |
|
|
Suicidal thoughts or urges
|
7 |
|
|
Sleepiness
|
7 |
|
|
Daytime sleepiness
|
6 |
|
|
Diarrhea
|
6 |
|
|
Stomach upset
|
6 |
|
|
Excessive dry mouth
|
6 |
|
|
Stomach pain
|
6 |
|
|
Vivid dreams
|
6 |
|
|
Excessive yawning
|
5 |
|
|
Frequent nausea
|
5 |
|
|
Heart palpitations
|
5 |
|
|
Frequent vertigo with nausea
|
5 |
|
|
Hyperactivity
|
4 |
|
|
Weight loss
|
4 |
|
|
Dry eyes
|
4 |
|
|
Serotonin syndrome
|
4 |
|
|
Rashes (redness, swelling)
|
4 |
|
|
Urinary hesitancy
|
4 |
|
|
Ringing in ears (tinnitus)
|
4 |
|
|
Sweating
|
4 |
|
|
Jittery feeling
|
4 |
|
|
Vomiting
|
4 |
|
|
Exhaustion
|
4 |
|
|
Emotional numbness or flatness
|
4 |
|
|
Increased insomnia
|
3 |
|
|
Withdrawal effects
|
3 |
|
|
Dizziness (vertigo)
|
3 |
|
|
Ejaculation delayed
|
3 |
|
|
Itching (pruritus)
|
3 |
|
|
Muscle twitching (fasciculations)
|
3 |
|
|
SSRI Discontinuation (withdrawal) Syndrome
|
3 |
|
|
Muscle spasms
|
3 |
|
|
Increased or worsened depression
|
3 |
|
|
Depression with anxiety
|
3 |
|
|
Swelling in legs, feet and ankles
|
3 |
|
|
No sexual desire
|
3 |
|
|
Increased appetite
|
3 |
|
|
Unrefreshing or poor sleep
|
3 |
|
|
Bruising
|
3 |
|
|
Dizziness with nausea
|
3 |
|
|
Excessive sleeping (hypersomnia)
|
3 |
|
|
Hallucinations
|
3 |
|
|
Nightmares
|
3 |
|
|
Panic attacks
|
3 |
|
|
Suicidal
|
3 |
|
|
Increased fatigue
|
3 |
|
|
Difficulty urinating occasionally
|
3 |
|
|
Pain in lower back
|
3 |
|
|
Edema (fluid retention)
|
2 |
|
|
Pain
|
2 |
|
|
Heartburn
|
2 |
|
|
Shortness of breath (dyspnea)
|
2 |
|
|
Acid reflux
|
2 |
|
|
Apathy
|
2 |
|
|
Tremor in hands
|
2 |
|
|
Abdominal bloating
|
2 |
|
|
Urinary retention
|
2 |
|
|
Bowel irritability
|
2 |
|
|
Bruxism (teeth grinding)
|
2 |
|
|
Seizures (grand mal or tonic-clonic)
|
2 |
|
|
Anxiety and frustration
|
2 |
|
|
Fever
|
2 |
|
|
Shaky hands
|
2 |
|
|
Elevated liver enzymes
|
2 |
|
|
Joint pain
|
2 |
|
|
Deadened emotions
|
2 |
|
|
None
|
2 |
|
|
Feeling of disconnection
|
2 |
|
|
Tachycardia (fast heart rate)
|
2 |
|
|
Irritability
|
2 |
|
|
Anger
|
2 |
|
|
Loss of energy
|
2 |
|
|
Feeling hot
|
2 |
|
|
Heart rate increased
|
2 |
|
|
Shakiness
|
2 |
|
|
Somnolence
|
2 |
|
|
Dizziness and feeling faint
|
2 |
|
|
Nervousness
|
2 |
|
|
Poor Concentration
|
2 |
|
|
Allergic reaction
|
2 |
|
|
Bloating
|
2 |
|
|
Aggression
|
2 |
|
|
Fluid retention weight gain
|
2 |
|
|
Suicidal ideation
|
2 |
|
|
Craving sweets sugar
|
2 |
|
|
Sex drive (libido) increased
|
2 |
|
|
Agitation with irritability
|
2 |
|
|
Anxiety attacks
|
2 |
|
|
Loss of balance
|
2 |
|
|
Mood changes
|
2 |
|
|
Problems with focusing eyes
|
2 |
|
|
Listlessness
|
2 |
|
|
Chest tightness
|
2 |
|
|
Chronic constipation
|
2 |
|
|
Constant tremors
|
2 |
|
|
Electric shock sensations
|
2 |
|
|
Constipation with occasional impaction
|
2 |
|
|
Antidepressant withdrawal syndrome
|
2 |
|
|
Side effects when dose skipped
|
2 |
|
|
Hypomania
|
2 |
|
|
Eye Twitching
|
1 |
|
|
Hives (urticaria)
|
1 |
|
|
Dissociation
|
1 |
|
|
Jumpy feeling
|
1 |
|
|
Constant vomiting
|
1 |
|
|
Extreme sedation
|
1 |
|
|
when you can't afford to stay on them its not as effective
|
1 |
|
|
Feelings of hopelessness
|
1 |
|
|
Loss of coordination
|
1 |
|
|
Loss of short term memory
|
1 |
|
|
stabbing and swelling pain stomach yellow bowel movements muddy pain
|
1 |
|
|
Agitation
|
1 |
|
|
Increased Hunger
|
1 |
|
|
Visual hallucinations
|
1 |
|
|
Sneezing
|
1 |
|
|
Chills
|
1 |
|
|
Pins and needles
|
1 |
|
|
Mood elevated or improved
|
1 |
|
|
Burning sensation in back
|
1 |
|
|
Swelling in ankle
|
1 |
|
|
Overstimulated
|
1 |
|
|
Loose stools
|
1 |
|
|
Thirst
|
1 |
|
|
Skin rash
|
1 |
|
|
Bad taste in mouth
|
1 |
|
|
Appetite change
|
1 |
|
|
Flu like symptoms
|
1 |
|
|
Urinary Tract Infection UTI
|
1 |
|
|
Hand twitches
|
1 |
|
|
Nerve pain (neuralgia)
|
1 |
|
|
Compulsive scratching
|
1 |
|
|
Sore throat (Pharyngitis)
|
1 |
|
|
Overeating
|
1 |
|
|
worsening of symptoms
|
1 |
|
|
Laziness
|
1 |
|
|
Sleep problems
|
1 |
|
|
Gas
|
1 |
|
|
Crying spells
|
1 |
|
|
"Lucite Encased" Head
|
1 |
|
|
Lose train of thought
|
1 |
|
|
Flatulence
|
1 |
|
|
Apathy to environment
|
1 |
|
|
Slowed thinking
|
1 |
|
|
Feeling worthless
|
1 |
|
|
Sporadic electric shock sensations in legs
|
1 |
|
|
noise in head
|
1 |
|
|
Loose bowel movements
|
1 |
|
|
Word fishing
|
1 |
|
|
Kidney stones
|
1 |
|
|
Dark, soft stools
|
1 |
|
|
Feeling of lump in throat
|
1 |
|
|
Cough
|
1 |
|
|
Raised body temperature
|
1 |
|
|
Sensitivity to sudden loud noises
|
1 |
|
|
Rash or skin problems
|
1 |
|
|
Muscle and joint pain
|
1 |
|
|
Chills/fever
|
1 |
|
|
Double vision (diplopia)
|
1 |
|
|
Tightness in hands
|
1 |
|
|
Cold intolerance
|
1 |
|
|
Spaced out
|
1 |
|
|
Inability to handle stress (bad stress reactions)
|
1 |
|
|
Overwhelming emotions
|
1 |
|
|
Itchy scalp
|
1 |
|
|
Headaches all day
|
1 |
|
|
Cognitive Confusion
|
1 |
|
|
Feeling of insides shaking
|
1 |
|
|
Bleeding (hemorrhage)
|
1 |
|
|
Mental confusion
|
1 |
|
|
Spinning dizziness (vertigo)
|
1 |
|
|
Absence of menstruation (amenorrhea)
|
1 |
|
|
Withdrawal effects with missed dose
|
1 |
|
|
Parkinsonism
|
1 |
|
|
Memory lapses (brain blinks)
|
1 |
|
|
Swelling in hands
|
1 |
|
|
strange ideas
|
1 |
|
|
Body odor
|
1 |
|
|
Bruise easily
|
1 |
|
|
sometimes wake up more sleepy then when I laid down
|
1 |
|
|
dilated pupils
|
1 |
|
|
Outburst of anger
|
1 |
|
|
Urine smell abnormal
|
1 |
|
|
Tremor in right thumb
|
1 |
|
|
Diarrhea while sleeping
|
1 |
|
|
Drug dependence
|
1 |
|
|
Feeling out of it
|
1 |
|
|
Binge eating in evening
|
1 |
|
|
Irregular menstrual periods
|
1 |
|
|
Seizure with staring episodes
|
1 |
|
|
Burning mouth syndrome
|
1 |
|
|
Feeling sick
|
1 |
|
|
muscle pain, legs, tendons, ankles, hands, wrist and lower arms
|
1 |
|
|
Anticipatory anxiety
|
1 |
|
|
Stimulant - interferes with sleep
|
1 |
|
|
Loss of sleep
|
1 |
|
|
Electric shock sensations in brain
|
1 |
|
|
Weird or strange dreams
|
1 |
|
|
Anxiety with missed dose
|
1 |
|
|
Heat intolerance
|
1 |
|
|
Drenching sweats during flares
|
1 |
|
|
Sleeplessness for first month
|
1 |
|
|
Accidental Fall
|
1 |
|
|
Uro-Genital Syndrome
|
1 |
|
|
Blood in stool
|
1 |
|
|
Incontinence
|
1 |
|
|
saw bugs
|
1 |
|
|
Liver damage
|
1 |
|
|
Increased urination
|
1 |
|
|
Tightness in throat and neck area
|
1 |
|
|
Diarrhea during titration
|
1 |
|
|
Pain worsened
|
1 |
|
|
Body Twitches
|
1 |
|
|
Sensitivity to medications
|
1 |
|
|
Pressure headaches
|
1 |
|
|
Vision difficulty
|
1 |
|
|
Generalized itching
|
1 |
|
|
Cold sweat
|
1 |
|
|
Numbness and Tingling with Pins and Needles
|
1 |
|
|
Impatient
|
1 |
|
|
Sjogrens syndrome
|
1 |
|
|
Increased urinary frequency
|
1 |
|
|
eye sight is getting worse and not because of age.
|
1 |
|
|
Whole body shaking
|
1 |
|
|
Memory problems
|
1 |
|
|
Episodic disorientation
|
1 |
|
|
Horrifying nightmares
|
1 |
|
|
Spasms
|
1 |
|
|
Adrenaline Rush
|
1 |
|
|
Sudden blasts of hunger
|
1 |
|
|
Stomach problems
|
1 |
|
|
Dark urine
|
1 |
|
|
Funny feeling in head.
|
1 |
|
|
Injection site irritation
|
1 |
|
|
Vivid Nightmares
|
1 |
|
|
Subjective tinnitus (clicking beating noise and pulsations in the ear)
|
1 |
|
|
Bowel problems
|
1 |
|
|
Bladder problems
|
1 |
|
|
Anorexia (appetite loss)
|
1 |
|
|
Vertigo
|
1 |
|
|
Increased anxiety
|
1 |
|
|
Swollen lips
|
1 |
|
|
Hoarseness of voice
|
1 |
|
|
Dyspepsia
|
1 |
|
|
Cramps in calf muscles
|
1 |
|
|
Occassional jittery feeling
|
1 |
|
|
Drowsy in a.m.
|
1 |
|
|
Wakefulness
|
1 |
|
|
Major Depressive Disorder
|
1 |
|
|
Difficulty urinating (dysuria)
|
1 |
|
|
Occasional euphoria
|
1 |
|
|
Liver pain
|
1 |
|
|
Fuzzy thinking
|
1 |
|
|
Sexual impotence
|
1 |
|
|
Eye pressure
|
1 |
|
|
IBS (Irritable Bowel Syndrome)
|
1 |
|
|
Hypertension
|
1 |
|
|
Swelling of throat
|
1 |
|
|
Internal tremor
|
1 |
|
|
insomnia, agitation, & anxiety when stopping treatment
|
1 |
|
|
Bad mood
|
1 |
|
|
Electric shock in face
|
1 |
|
|
Hot and cold flashes
|
1 |
|
|
over heating, to the point of chest tighting and forced to not move
|
1 |
|
|
weight gain,swelling in spinal area ,hands and feet
|
1 |
|
|
Daytime tiredness
|
1 |
|
|
Insomnia agitation
|
1 |
|
|
Not interested in sex
|
1 |
|
|
at first very sleepy not now though
|
1 |
|
|
Dizziness with disorientation
|
1 |
|
|
not sure if it's affecting my memory and or response time or if that is medical problem
|
1 |
|
|
Don't remember
|
1 |
|
|
Breakthrough intermenstrual bleeding
|
1 |
|
|
Dry mouth at night
|
1 |
|
|
triggered rapid cycling, suicide attempt
|
1 |
|
|
tired, nonchalant attitude.
|
1 |
|
|
some relief in pain and depression
|
1 |
|
|
Thick head
|
1 |
|
|
Uncontrollable shaking
|
1 |
|
|
Male sexual dysfunction
|
1 |
|
|
Alternating constipation and diarrhea
|
1 |
|
|
Increased thirst
|
1 |
|
|
Sick to my stomach
|
1 |
|
|
Body Tingling
|
1 |
|
|
Heavy sweating anytime, day or night
|
1 |
|
|
spiking blood pressure
|
1 |
|
|
Meniere's Disease
|
1 |
|
|
Weakness in legs
|
1 |
|
|
thick head & flat mood
|
1 |
|
|
Spinal Stenosis
|
1 |
|
|
Dizziness/walking like I'm drunk
|
1 |
|
|
disequalibrium
|
1 |
|
|
Oversleeping (too much sleep)
|
1 |
|
|
Tired legs
|
1 |
|
|
sleepy-loopy
|
1 |
|
|
legs seemed to be paralyzed for a minute
|
1 |
|
|
Stomach ache
|
1 |
|
|
Bladder pain
|
1 |
|
|
Generalized weakness (asthenia)
|
1 |
|
|
hard to control blood sugars
|
1 |
|
|
Dry tongue
|
1 |
|
|
Sadness
|
1 |
|
|
Confusion
|
1 |
|
|
Lightheadedness
|
1 |
|
|
Acne
|
1 |
|
|
Urinary tract pain
|
1 |
|
|
Narrow (closed) angle glaucoma right eye
|
1 |
|
|
Dizziness with hypotension upon standing
|
1 |
|
|
Neck pain
|
1 |
|
|
Inability to experience pleasure (anhedonia)
|
1 |
|
|
Frustration
|
1 |
|
|
Primary Insomnia
|
1 |
|
|
Restlessness
|
1 |
|
|
Chronic Hyperglycemia
|
1 |
|
|
An overall crappy feeling all the time
|
1 |
|
|
Menstruation differences
|
1 |
|
|
Joints ache (whole body)
|
1 |
|
|
Crying for good reason
|
1 |
|
|
Orthostatic/Postural Hypotension
|
1 |
|
|
Occasional nausea and vomiting
|
1 |
|
|
Preoccupation with food
|
1 |
|
|
Tremor
|
1 |
|
|
Crawling sensations in skin
|
1 |
|
|
Menstrual cramps
|
1 |
|
|
flat affect
|
1 |
|
|
Self harm thoughts or urges
|
1 |
|
|
Muscle fatigue
|
1 |
|
|
Bipolar rapid cycling
|
1 |
|
|
Heart palpitations then feel faint
|
1 |
|
|
Cold and clammy
|
1 |
|
|
Tension headaches
|
1 |
|
|
Feeling strange
|
1 |
|
|
Buzzing Sensation of Body
|
1 |
|
|
Paresthesia
|
1 |
|
|
See all
372 reported side effects
▼
See top
6 reported side effects
▲
|
Currently Taking Duloxetine
A bar graph
Stopped Taking Duloxetine
A bar graph
Adherence
Taking treatment as prescribed
Adherence of Duloxetine
Always |
1243
|
85%
|
|
Usually |
142
|
10%
|
|
Sometimes |
16
|
1%
|
|
Never |
57
|
4%
|
|
Burden
Difficulty being on treatment
Burden of Duloxetine
Cost
Paid out of pocket
Cost of Duloxetine
$200+ |
28
|
3%
|
|
$100-199 |
83
|
8%
|
|
$50-99 |
186
|
19%
|
|
$25-49 |
294
|
29%
|
|
< $25 |
398
|
40%
|
|
See more information,
including instructions, precautions, side effects, and interactions.
