Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

What is it like to have Major Depressive Disorder?

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

What do patients take to treat Major Depressive Disorder and its symptoms?

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Cymbalta, Cymgen, Yelate) 1 more
Type
Prescription Drug
How many have tried
557
Tried for
Major Depressive Disorder (502) Depressed mood (124)
6 more
Treatment name(s)

(Aplenzin, Budeprion SR, Budeprion XL) 12 more
Type
Prescription Drug
How many have tried
539
Tried for
Major Depressive Disorder (487) Depressed mood (101)
6 more
Treatment name(s)
Type
Psychotherapy
How many have tried
470
Tried for
Major Depressive Disorder (464) Depressed mood (11)
6 more
Treatment name(s)

(Altruline, Apo-Sertraline, Daxid) 11 more
Type
Prescription Drug
How many have tried
438
Tried for
Major Depressive Disorder (400) Depressed mood (87)
6 more
Treatment name(s)

(APO-Citalopram, Alcytan, Celexa) 15 more
Type
Prescription Drug
How many have tried
427
Tried for
Major Depressive Disorder (382) Depressed mood (89)
3 more
Treatment name(s)

(Actan, Flunil, Fluxene) 15 more
Type
Prescription Drug
How many have tried
403
Tried for
Major Depressive Disorder (357) Depressed mood (90)
5 more
Treatment name(s)

(Effexor, Effexor XR, Novo-Venlafaxine XR) 9 more
Type
Prescription Drug
How many have tried
397
Tried for
Major Depressive Disorder (374) Depressed mood (73)
3 more
Treatment name(s)

(Cipralex, Es Pramcit, Esipram) 6 more
Type
Prescription Drug
How many have tried
286
Tried for
Major Depressive Disorder (245) Depressed mood (63)
3 more
Treatment name(s)

(APO Clonazepam, Clonex, Clonotril) 7 more
Type
Prescription Drug
How many have tried
241
Tried for
Anxious mood (219) Insomnia (25)
5 more
Treatment name(s)

(Cobalt-Quetiapine, Dopaquel, Ketipinor) 4 more
Type
Prescription Drug
How many have tried
160
Tried for
Insomnia (120) Major Depressive Disorder (37)
3 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments for Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Treatment name(s)

(Cymbalta, Cymgen, Yelate) 1 more
Perceived effectiveness
for Major Depressive Disorder (189 evaluations)
Side effects
Nausea Weight gain 128 more
How many evaluations
297
Tried for
Major Depressive Disorder (502) Depressed mood (124)
6 more
Treatment name(s)

(Aplenzin, Budeprion SR, Budeprion XL) 12 more
Perceived effectiveness
for Major Depressive Disorder (206 evaluations)
Side effects
Anxious mood Nausea 113 more
How many evaluations
284
Tried for
Major Depressive Disorder (487) Depressed mood (101)
6 more
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (102 evaluations)
Side effects
Anxious mood Anger 17 more
How many evaluations
128
Tried for
Major Depressive Disorder (464) Depressed mood (11)
6 more
Treatment name(s)

(Altruline, Apo-Sertraline, Daxid) 11 more
Perceived effectiveness
for Major Depressive Disorder (172 evaluations)
Side effects
Weight gain Fatigue 118 more
How many evaluations
221
Tried for
Major Depressive Disorder (400) Depressed mood (87)
6 more
Treatment name(s)

(APO-Citalopram, Alcytan, Celexa) 15 more
Perceived effectiveness
for Major Depressive Disorder (171 evaluations)
Side effects
Dry mouth Sex drive (libido) decreased 88 more
How many evaluations
229
Tried for
Major Depressive Disorder (382) Depressed mood (89)
3 more
Treatment name(s)

(Actan, Flunil, Fluxene) 15 more
Perceived effectiveness
for Major Depressive Disorder (143 evaluations)
Side effects
Nausea Vivid dreams 101 more
How many evaluations
209
Tried for
Major Depressive Disorder (357) Depressed mood (90)
5 more
Treatment name(s)

(Effexor, Effexor XR, Novo-Venlafaxine XR) 9 more
Perceived effectiveness
for Major Depressive Disorder (154 evaluations)
Side effects
Dry mouth Weight gain 112 more
How many evaluations
192
Tried for
Major Depressive Disorder (374) Depressed mood (73)
3 more
Treatment name(s)

(Cipralex, Es Pramcit, Esipram) 6 more
Perceived effectiveness
for Major Depressive Disorder (110 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 76 more
How many evaluations
161
Tried for
Major Depressive Disorder (245) Depressed mood (63)
3 more
Treatment name(s)

(APO Clonazepam, Clonex, Clonotril) 7 more
Perceived effectiveness
for Anxious mood (104 evaluations)
Side effects
Drowsiness Sleepiness 40 more
How many evaluations
132
Tried for
Anxious mood (219) Insomnia (25)
5 more
Treatment name(s)

(Cobalt-Quetiapine, Dopaquel, Ketipinor) 4 more
Perceived effectiveness
for Insomnia (70 evaluations)
Side effects
Weight gain Excessive daytime sleepiness (somnolence) 46 more
How many evaluations
89
Tried for
Insomnia (120) Major Depressive Disorder (37)
3 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 228
20s 2,403
30s 3,461
40s 3,962
50s 3,292
60s 1,268
70+ 180

Gender

Distribution of females vs. males

77% Females
23% Males
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 3,875
20-29 years 1,536
30-39 years 1,039
40-49 years 561
50-59 years 186
60-69 years 18
70+ years 2

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 11,081
Not Diagnosed 1,960

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: