Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
552
Tried for
Major Depressive Disorder (498) Depressed mood (121)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
530
Tried for
Major Depressive Disorder (484) Depressed mood (91)
6 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
464
Tried for
Major Depressive Disorder (458) Depressed mood (11)
6 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
426
Tried for
Major Depressive Disorder (395) Depressed mood (80)
6 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
412
Tried for
Major Depressive Disorder (380) Depressed mood (75)
3 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
399
Tried for
Major Depressive Disorder (376) Depressed mood (75)
3 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
392
Tried for
Major Depressive Disorder (354) Depressed mood (81)
5 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
279
Tried for
Major Depressive Disorder (245) Depressed mood (55)
3 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
233
Tried for
Anxious mood (214) Insomnia (22)
4 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
161
Tried for
Insomnia (144) Major Depressive Disorder (27)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (189 evaluations)
Side effects
Nausea Weight gain 124 more
How many evaluations
294
Tried for
Major Depressive Disorder (498) Depressed mood (121)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (205 evaluations)
Side effects
Anxious mood Nausea 117 more
How many evaluations
274
Tried for
Major Depressive Disorder (484) Depressed mood (91)
6 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (103 evaluations)
Side effects
Anxious mood Anger 17 more
How many evaluations
131
Tried for
Major Depressive Disorder (458) Depressed mood (11)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (174 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 115 more
How many evaluations
217
Tried for
Major Depressive Disorder (395) Depressed mood (80)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (170 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 84 more
How many evaluations
219
Tried for
Major Depressive Disorder (380) Depressed mood (75)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (160 evaluations)
Side effects
Dry mouth Weight gain 108 more
How many evaluations
191
Tried for
Major Depressive Disorder (376) Depressed mood (75)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (140 evaluations)
Side effects
Nausea Anxious mood 94 more
How many evaluations
193
Tried for
Major Depressive Disorder (354) Depressed mood (81)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (113 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 78 more
How many evaluations
159
Tried for
Major Depressive Disorder (245) Depressed mood (55)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (108 evaluations)
Side effects
Drowsiness Sleepiness 41 more
How many evaluations
132
Tried for
Anxious mood (214) Insomnia (22)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (74 evaluations)
Side effects
Excessive daytime sleepiness (somnolence) Dizziness 44 more
How many evaluations
81
Tried for
Insomnia (144) Major Depressive Disorder (27)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 224
20s 2,419
30s 3,560
40s 4,061
50s 3,409
60s 1,344
70+ 188

Gender

Distribution of females vs. males

77% Females
23% Males
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 3,928
20-29 years 1,561
30-39 years 1,053
40-49 years 572
50-59 years 184
60-69 years 18
70+ years 2

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 11,203
Not Diagnosed 1,960

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: