Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
552
Tried for
Major Depressive Disorder (498) Depressed mood (121)
6 more
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Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
530
Tried for
Major Depressive Disorder (485) Depressed mood (92)
6 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
468
Tried for
Major Depressive Disorder (462) Depressed mood (11)
6 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
427
Tried for
Major Depressive Disorder (395) Depressed mood (79)
6 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
417
Tried for
Major Depressive Disorder (380) Depressed mood (81)
3 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
399
Tried for
Major Depressive Disorder (374) Depressed mood (78)
3 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
390
Tried for
Major Depressive Disorder (349) Depressed mood (84)
5 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
282
Tried for
Major Depressive Disorder (245) Depressed mood (59)
3 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
239
Tried for
Anxious mood (217) Insomnia (23)
4 more
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Treatment name(s)

(Seroquel)
Type
Prescription Drug
How many have tried
157
Tried for
Insomnia (118) Major Depressive Disorder (37)
2 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (186 evaluations)
Side effects
Nausea Weight gain 124 more
How many evaluations
291
Tried for
Major Depressive Disorder (498) Depressed mood (121)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (207 evaluations)
Side effects
Anxious mood Nausea 115 more
How many evaluations
279
Tried for
Major Depressive Disorder (485) Depressed mood (92)
6 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (102 evaluations)
Side effects
Anxious mood Anger 17 more
How many evaluations
128
Tried for
Major Depressive Disorder (462) Depressed mood (11)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (172 evaluations)
Side effects
Weight gain Fatigue 115 more
How many evaluations
214
Tried for
Major Depressive Disorder (395) Depressed mood (79)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (171 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 89 more
How many evaluations
222
Tried for
Major Depressive Disorder (380) Depressed mood (81)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (160 evaluations)
Side effects
Dry mouth Weight gain 116 more
How many evaluations
197
Tried for
Major Depressive Disorder (374) Depressed mood (78)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (139 evaluations)
Side effects
Nausea Anxious mood 96 more
How many evaluations
199
Tried for
Major Depressive Disorder (349) Depressed mood (84)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (113 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 78 more
How many evaluations
159
Tried for
Major Depressive Disorder (245) Depressed mood (59)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (103 evaluations)
Side effects
Drowsiness Sleepiness 40 more
How many evaluations
130
Tried for
Anxious mood (217) Insomnia (23)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Seroquel)
Perceived effectiveness
for Insomnia (70 evaluations)
Side effects
Weight gain Excessive daytime sleepiness (somnolence) 46 more
How many evaluations
89
Tried for
Insomnia (118) Major Depressive Disorder (37)
2 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 229
20s 2,406
30s 3,520
40s 4,008
50s 3,352
60s 1,317
70+ 185

Gender

Distribution of females vs. males

77% Females
23% Males
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 3,906
20-29 years 1,547
30-39 years 1,049
40-49 years 568
50-59 years 185
60-69 years 18
70+ years 2

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 11,150
Not Diagnosed 1,960

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: