Eligibility

Ages Eligible for Study

18 years and up

Genders Eligible for Study

Both

Keywords

Stroke, Dementia, Dementia, Vascular, Alzheimers Disease, Intracranial Hemorrhage, and Brain Ischemia

Sponsors

Other

Ludwig-Maximilians - University of Munich

Inclusion Criteria

- Age ≥ 18 years

- Language: German

- Acute stroke that occurred within the last 3 days as defined by:

acute focal neurological deficit in combination with one of the following:

- An acute ischemic infarct as documented by either a DWI positive lesion on MR imaging
or a new lesion on a delayed CT scan

- An intracerebral hemorrhage as documented on CT or MRI

- An informant of the patient is available

- Written informed consent by patient prior to study participation

- Willingness to participate in follow-up

Exclusion Criteria

- IQCODE > 64 or diagnosis of dementia

- Patients living at distance > 30km of the participating center

- Patients transferred from an outside hospital (to avoid possible selection bias)

- Patients presenting a stroke going back more than 72 hours

- Patients presenting one of the following diseases: cerebral venous thrombosis,
traumatic cerebral haemorrhage, intracerebral haemorrhage because of a known or
image-guided assumed vascular malformation, pure meningeal or intraventricular
haemorrhage

- Patients presenting a malignant disease with life expectancy < 3years
Contraindication for MRI

- Participation in an intervention/AMG-study

Detailed Description

The primary aim of the DEDEMAS (Determinants of Dementia After Stroke) study is to identify predictors of post stroke dementia (PSD). A particular focus will be on biological markers (neuroimaging, biochemical markers derived from blood) and on interactions between vascular and neurodegenerative mechanisms. For this purpose patients with an acute stroke and without prior dementia will be followed for 60 months.