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What is Dextromethorphan with Quinidine?

A dextromethorphan-quinidine combination was studied for its effect on inappropriate laughing and crying episodes experienced by some patients with brain injury or brain degeneration due to certain diseases. The incongruous laughing and crying episodes are due to pseudobulbar affect.

Reported Side Effects

Side effects as an overall problem

Severe
1
Moderate
4
Mild
0
None
15

Commonly reported side effects, conditions, and hospitalizations associated with Dextromethorphan with Quinidine

Diarrhea 2
Fatigue 1
Dizziness 1
Thrush 1
Sleepiness 1

Reported Dosages

Frequently reported dosages based on patients currently taking Dextromethorphan with Quinidine. See all 16 dosages

  daily 1 cap(s) daily 2 mg daily 2 cap(s) daily 10 mg daily 20 mg daily 30 mg daily 40 mg daily 50 mg daily 60 mg daily
  5 Number of Patients: 5 2 Number of Patients: 2 3 Number of Patients: 3 8 Number of Patients: 8 5 Number of Patients: 5 3 Number of Patients: 3 4 Number of Patients: 4 5 Number of Patients: 5 3 Number of Patients: 3 5 Number of Patients: 5  

Reported Stop Reasons

Why Patients Stopped Taking Dextromethorphan with Quinidine (multiple reasons could be selected)
Reason # Patients Percentage of patients
Did not seem to work 4   Did not seem to work: 44%
Side effects too severe 3   Side effects too severe: 33%
Expense 2   Expense: 22%
Course of treatment ended 2   Course of treatment ended: 22%

See all 9 patients who’ve stopped taking Dextromethorphan with Quinidine

Currently Taking Dextromethorphan with Quinidine

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Stopped Taking Dextromethorphan with Quinidine

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
0

Reported Adherence, Burden & Cost See details from patient evaluations

Adherence

Taking treatment as prescribed

Adherence of Dextromethorphan with Quinidine

Always
16 80%
Usually
3 15%
Sometimes
0 0%
Never
1 5%

Burden

Difficulty being on treatment

Burden of Dextromethorphan with Quinidine

Very
0 0%
Somewhat
1 5%
A little
2 10%
Not at all
17 85%

Cost

Paid out of pocket

Cost of Dextromethorphan with Quinidine

$200+
1 8%
$100-199
0 0%
$50-99
2 17%
$25-49
6 50%
< $25
3 25%

Report created on May 25, 2012.