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What is Methotrexate?

Methotrexate is an antineoplastic drug used in the treatment of cancer. Also used as an antirheumatic for rheumatoid arthritis. Off label use in treatment of Crohn's disease and ectopic pregnancy. Experimental use in MS. It is given by mouth, by injection, via IV or intrathecally.

Reported Purpose & Efficacy

Reasons and Efficacy
Purpose # of patients
# of patients with evaluations Efficacy
Major
Moderate
Slight
None
Can’t tell
RA (Rheumatoid Arthritis) 375 89 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
MS (Multiple Sclerosis) 70 16 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
Psoriatic arthritis 47 10 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_cant_tell
Rheumatoid Arthritis 44 12 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none
Psoriasis 40 12 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_cant_tell
Other 29 8 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none

See all 547 patients currently taking Methotrexate

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Reported Side Effects

Side effects as an overall problem

Severe
 46
Moderate
 47
Mild
 46
None
 30

Commonly reported side effects, conditions, and hospitalizations associated with Methotrexate

Fatigue 30
Nausea 28
Hair loss (alopecia) 24
Stomach upset 13
Headaches 11
Nausea and vomiting 10
See all 100 reported side effects ▼ See top 6 reported side effects ▲

Reported Dosages

Frequently reported dosages based on patients currently taking Methotrexate. See all 74 dosages ►

  0.6 mg weekly 7.5 mg weekly 10 mg weekly 12.5 mg weekly 15 mg weekly 17.5 mg weekly 20 mg weekly 22.5 mg weekly 25 mg weekly 30 mg weekly
  6 Number of Patients: 6 42 Number of Patients: 42 54 Number of Patients: 54 35 Number of Patients: 35 91 Number of Patients: 91 24 Number of Patients: 24 106 Number of Patients: 106 7 Number of Patients: 7 88 Number of Patients: 88 8 Number of Patients: 8  

Reported Stop Reasons

Why Patients Stopped Taking Methotrexate (multiple reasons could be selected)
Reason # Patients Percentage of patients
Side effects too severe 117   Side effects too severe: 54%
Did not seem to work 72   Did not seem to work: 33%
Doctor's advice 51   Doctor's advice: 24%
Other 29   Other: 13%
Course of treatment ended 15   Course of treatment ended: 7%
Personal research 5   Personal research: 2%
Expense 4   Expense: 2%
Change in health plan coverage 4   Change in health plan coverage: 2%
Not indicated 3   Not indicated: 1%

See all 204 patients who’ve stopped taking Methotrexate

Reported Duration See details about how long patients take this treatment ▼

Currently Taking Methotrexate

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Stopped Taking Methotrexate

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations ▼

Adherence

Taking treatment as prescribed

Adherence of Methotrexate

Always
 148 88%
Usually
 17 10%
Sometimes
 2 1%
Never
 2 1%

Burden

Difficulty being on treatment

Burden of Methotrexate

Very
 12 7%
Somewhat
 36 21%
A little
 29 17%
Not at all
 92 54%

Cost

Paid out of pocket

Cost of Methotrexate

$200+
 0 0%
$100-199
 2 2%
$50-99
 4 4%
$25-49
 10 10%
< $25
 83 82%

See more information, including instructions, precautions, side effects, and interactions.

Report created on February 11, 2012.