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What is glycopyrrolate?

Glycopyrrolate reduces the secretions of certain organs in the body.

Glycopyrrolate helps to control conditions such as peptic ulcers that involve excessive stomach acid production.

The injectable form of glycopyrrolate is also used to reduce saliva, nasal, lung, and stomach secretions and to help control heart rate during surgery.

Glycopyrrolate may also be used for purposes other than those listed in this medication guide.

Precautions

Instructions

Side-effects

Interactions

Precautions

Do not take glycopyrrolate if you have

• kidney disease;
• a blockage of your urinary tract (difficulty urinating);
• a blockage in your intestines, severe ulcerative colitis, or ulcerative colitis complicated by toxic megacolon;
• glaucoma; or
• myasthenia gravis.

Before taking this medication, tell your doctor if you have

• numbness or tingling in your hands or feet;
• liver disease;
• ulcerative colitis;
• thyroid problems;
• high blood pressure, an irregular heartbeat, or any type of heart disease;
• hiatal hernia or reflux disease;
• enlargement of the prostate; or
• asthma, chronic lung disease, or allergies.

You may not be able to take glycopyrrolate, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether glycopyrrolate will harm an unborn baby. Do not take glycopyrrolate without first talking to your doctor if you are pregnant.

It is not known whether glycopyrrolate passes into breast milk. Do not take glycopyrrolate without first talking to your doctor if you are breast-feeding a baby.

Use caution when driving, operating machinery, or performing other hazardous activities. Glycopyrrolate may cause dizziness, drowsiness, or blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking glycopyrrolate.

Avoid becoming overheated in hot weather. Glycopyrrolate increases the risk of heat stroke because it causes decreased sweating.

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Instructions

Seek emergency medical attention.

Symptoms of a glycopyrrolate overdose include headache; nausea; vomiting; dry mouth; difficulty swallowing; blurred vision; dilated pupils; hot, dry skin; dizziness; drowsiness; confusion; anxiety; seizures; weak pulse; and an irregular heartbeat.

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

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Side-effects

If you experience any of the following serious side effects, stop taking glycopyrrolate and seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
• an irregular or fast heart rate;
• rash or flushing; or
• eye pain.

Other, less serious side effects may be more likely to occur. Continue to take glycopyrrolate and talk to your doctor if you experience

• headache, dizziness, or lightheadedness;
• weakness or nervousness;
• blurred vision, large pupils, or sensitivity of the eyes to bright light;
• nausea, bloating, heartburn, or constipation;
• changes in taste;
• difficulty urinating;
• decreased sweating; or
• nasal congestion, stuffiness, or a dry mouth.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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Interactions

Many other drugs may increase the side effects of glycopyrrolate. Before taking this medication, tell your doctor if you are taking any of the following medicines:

• amantadine (Symmetrel);
• quinidine (Quinaglute, Cardioquin, Quinora, Quinidex);
• antihistamines such as diphenhydramine (Benadryl, many others), brompheniramine (Dimetapp, Bromphen, many others), triprolidine (Actifed, others), and chlorpheniramine (Chlor-Trimeton, others), which are found in many over-the-counter and prescription cough, cold, and allergy medications;
• decongestants and appetite suppressants such as phenylpropanolamine (Dexatrim, others), phenylephrine (Neo-Synephrine, others), and pseudoephedrine (Sudafed, others), which are also found in many over-the-counter and prescription products;
• phenothiazines such as chlorpromazine (Thorazine) and prochlorperazine (Compazine);
• other commonly used phenothiazines, including fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), thioridazine (Mellaril), trifluoperazine (Stelazine), and promazine (Sparine);
• tricyclic antidepressants such as amitriptyline (Elavil, Endep), doxepin (Sinequan), and nortriptyline (Pamelor); or
• other commonly used tricyclic antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), protriptyline (Vivactil), and trimipramine (Surmontil).

Glycopyrrolate may increase the level of digoxin (Lanoxin, Lanoxicaps) in your blood. Tell your doctor if you are taking digoxin so that your digoxin levels can be monitored and changes in your dosage can be made if necessary.

Drugs other than those listed here may also interact with glycopyrrolate. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

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